Chronic pancreatitis: A path to pancreatic cancer

被引：106

作者：

Pinho, Andreia V. ^{[1
]}

Chantrill, Lorraine ^{[1
,2
]}

Rooman, Ilse ^{[1
,3
,4
]}

机构：

[1] Garvan Inst Med Res, Kinghorn Canc Ctr, Canc Res Program, Sydney, NSW 2010, Australia

[2] Campbelltown Hosp, Macarthur Canc Therapy Ctr, Campbelltown, NSW, Australia

[3] Univ New S Wales, St Vincents Clin Sch, Sydney, NSW, Australia

[4] Vrije Univ Brussel, Diabet Res Ctr, Brussels, Belgium

来源：

CANCER LETTERS | 2014年 / 345卷 / 02期

关键词：

Pancreatic cancer; Pancreatitis; Acinar to ductal metaplasia; Oxidative stress; Inflammation; Dedifferentiation; FACTOR-KAPPA-B; BETA-CELL; INTRAEPITHELIAL NEOPLASIA; ACINAR-CELL; ONCOGENIC KRAS; MOUSE MODEL; DUCTAL ADENOCARCINOMA; EXOCRINE PANCREAS; OXIDATIVE STRESS; RAS ACTIVITY;

D O I：

10.1016/j.canlet.2013.08.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chronic pancreatitis predisposes to pancreatic cancer development and both diseases share a common etiology. A central role has been proposed for the digestive enzyme-secreting acinar cell that can undergo ductal metaplasia in the inflammatory environment of pancreatitis. This metaplastic change is now a recognised precursor of pancreatic cancer. Inflammatory molecules also foster tumour growth through autocrine and paracrine effects in the epithelium and the stroma. These insights have raised new opportunities such as the manipulation of inflammation as a preventive and/or therapeutic strategy for pancreatic cancer. Finally, we address the need for an in-depth study of the pancreatic acinar cells. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：203 / 209

页数：7

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