Rheumatoid Arthritis-Associated MicroRNA-155 Targets SOCS1 and Upregulates TNF-α and IL-1β in PBMCs

被引:113
作者
Li, Xiaochuan [1 ]
Tian, Feng [1 ]
Wang, Fei [1 ]
机构
[1] China Med Univ, Shengjing Hosp, Dept Hand & Foot Surg, Shenyang 110001, Peoples R China
关键词
miR-155; rheumatoid arthritis; TNF- and IL-1; SOCS1; SYNOVIAL TISSUE; T-CELLS; EXPRESSION; CLASSIFICATION; CRITERIA; GENE;
D O I
10.3390/ijms141223910
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
miR-155 plays a crucial role in proinflammatory activation. This study was carried out to assess the association of abnormal expression of miR-155 in peripheral blood of patients with Rheumatoid arthritis with the expression of TNF- and IL-1. Release of TNF- and IL-1, and expression of miR-155 were determined in RA peripheral blood or peripheral blood macrophages, followed by correlation analysis of the cytokines release and miR-155 expression. Furthermore, in vitro studies indicate that miR-155 inhibited the expression of SOCS1. Our results suggest that there is a correlation between the high-level expression of miR-155 and the enhanced expression of TNF- and IL-1. miR-155 targets and suppresses the expression of SOCS1, and the decrease of SOCS1 may lead to the upregulation of TNF- and IL-1.
引用
收藏
页码:23910 / 23921
页数:12
相关论文
共 31 条
[1]   DEVELOPMENT OF CRITERIA FOR THE CLASSIFICATION AND REPORTING OF OSTEOARTHRITIS - CLASSIFICATION OF OSTEOARTHRITIS OF THE KNEE [J].
ALTMAN, R ;
ASCH, E ;
BLOCH, D ;
BOLE, G ;
BORENSTEIN, D ;
BRANDT, K ;
CHRISTY, W ;
COOKE, TD ;
GREENWALD, R ;
HOCHBERG, M ;
HOWELL, D ;
KAPLAN, D ;
KOOPMAN, W ;
LONGLEY, S ;
MANKIN, H ;
MCSHANE, DJ ;
MEDSGER, T ;
MEENAN, R ;
MIKKELSEN, W ;
MOSKOWITZ, R ;
MURPHY, W ;
ROTHSCHILD, B ;
SEGAL, M ;
SOKOLOFF, L ;
WOLFE, F .
ARTHRITIS AND RHEUMATISM, 1986, 29 (08) :1039-1049
[2]   THE AMERICAN-RHEUMATISM-ASSOCIATION 1987 REVISED CRITERIA FOR THE CLASSIFICATION OF RHEUMATOID-ARTHRITIS [J].
ARNETT, FC ;
EDWORTHY, SM ;
BLOCH, DA ;
MCSHANE, DJ ;
FRIES, JF ;
COOPER, NS ;
HEALEY, LA ;
KAPLAN, SR ;
LIANG, MH ;
LUTHRA, HS ;
MEDSGER, TA ;
MITCHELL, DM ;
NEUSTADT, DH ;
PINALS, RS ;
SCHALLER, JG ;
SHARP, JT ;
WILDER, RL ;
HUNDER, GG .
ARTHRITIS AND RHEUMATISM, 1988, 31 (03) :315-324
[3]   Epigenetics and autoimmunity [J].
Brooks, Wesley H. ;
Le Dantec, Christelle ;
Pers, Jacques-Olivier ;
Youinou, Pierre ;
Renaudineau, Yves .
JOURNAL OF AUTOIMMUNITY, 2010, 34 (03) :J207-J219
[4]   MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells [J].
Ceppi, Maurizio ;
Pereira, Patricia M. ;
Dunand-Sauthier, Isabelle ;
Barras, Emmanuele ;
Reith, Walter ;
Santos, Manuel A. ;
Pierre, Philippe .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (08) :2735-2740
[5]   Understanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritis [J].
Choy, Ernest .
RHEUMATOLOGY, 2012, 51 :V3-V11
[6]   A role for Dicer in immune regulation [J].
Cobb, Bradley S. ;
Hertweck, Arnulf ;
Smith, James ;
O'Connor, Eric ;
Graf, Daniel ;
Cook, Terence ;
Smale, Stephen T. ;
Sakaguchi, Shimon ;
Livesey, Frederick J. ;
Fisher, Amanda G. ;
Merkenschlager, Matthias .
JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (11) :2519-2527
[7]   Processing of primary microRNAs by the Microprocessor complex [J].
Denli, AM ;
Tops, BBJ ;
Plasterk, RHA ;
Ketting, RF ;
Hannon, GJ .
NATURE, 2004, 432 (7014) :231-235
[8]   Role of cytokines in rheumatoid arthritis [J].
Feldmann, M ;
Brennan, FM ;
Maini, RN .
ANNUAL REVIEW OF IMMUNOLOGY, 1996, 14 :397-440
[9]   The role of microRNA in rheumatoid arthritis and other autoimmune diseases [J].
Furer, Victoria ;
Greenberg, Jeffrey D. ;
Attur, Mukundan ;
Abramson, Steven B. ;
Pillinger, Michael H. .
CLINICAL IMMUNOLOGY, 2010, 136 (01) :1-15
[10]   MicroRNA-155 Functions as an OncomiR in Breast Cancer by Targeting the Suppressor of Cytokine Signaling 1 Gene [J].
Jiang, Shuai ;
Zhang, Hong-Wei ;
Lu, Ming-Hua ;
He, Xiao-Hong ;
Li, Yong ;
Gu, Hua ;
Liu, Mo-Fang ;
Wang, En-Duo .
CANCER RESEARCH, 2010, 70 (08) :3119-3127