Nitric oxide affects short-term olfactory memory in the antennal lobe of Manduca sexta

被引:10
作者
Gage, Stephanie L. [1 ]
Daly, Kevin C. [2 ]
Nighorn, Alan [1 ]
机构
[1] Univ Arizona, Tucson, AZ 85721 USA
[2] W Virginia Univ, Morgantown, WV 26506 USA
基金
美国国家卫生研究院;
关键词
olfaction; learning; memory; circadian; NOS inhibition; moth; SYNTHASE IMPAIRS; GLOMERULAR LAYER; APIS-MELLIFERA; BULB; INHIBITION; SYSTEM; INFORMATION; HAWKMOTHS; CELLS; MOTH;
D O I
10.1242/jeb.086694
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Nitric oxide (NO) is thought to play an important neuromodulatory role in olfaction. We are using the hawkmoth Manduca sexta to investigate the function of NO signaling in the antennal lobe (AL; the primary olfactory network in invertebrates). We have found previously that NO is present at baseline levels, dramatically increases in response to odor stimulation, and alters the electrophysiology of AL neurons. It is unclear, however, how these effects contribute to common features of olfactory systems such as olfactory learning and memory, odor detection and odor discrimination. In this study, we used chemical detection and a behavioral approach to further examine the function of NO in the AL. We found that basal levels of NO fluctuate with the daily light cycle, being higher during the nocturnal active period. NO also appears to be necessary for short-term olfactory memory. NO does not appear to affect odor detection, odor discrimination between dissimilar odorants, or learning acquisition. These findings suggest a modulatory role for NO in the timing of olfactory-guided behaviors.
引用
收藏
页码:3294 / 3300
页数:7
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