Adjuvant treatment in resected non-small cell lung cancer: Current and future issues

被引：12

作者：

Remon, Jordi ^{[1
]}

Lianes, Pilar ^{[1
]}

Martinez, Susana ^{[1
]}

Velasco, Montserrat ^{[1
]}

Querol, Rosa ^{[1
]}

Zanui, Montserrat ^{[1
]}

机构：

[1] Hosp Mataro, Dept Med Oncol, Barcelona 08304, Spain

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2013年 / 88卷 / 02期

关键词：

Adjuvant chemotherapy; Lung cancer; Stage IB-IIIA; VINORELBINE PLUS CISPLATIN; INSTITUTE-OF-CANADA; III BETA-TUBULIN; POOLED ANALYSIS; PHASE-III; STAGE-II; DNA-REPAIR; POSTOPERATIVE RADIOTHERAPY; 1ST-LINE TREATMENT; PROGNOSTIC-FACTOR;

D O I：

10.1016/j.critrevonc.2013.05.017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The cornerstone of treatment for early-stage non-small cell lung cancer (NSCLC) has been surgical resection. In the last five years two phase III trials have provided evidence of adjuvant platinum-based chemotherapy for completely resected stage II-IIIA patients. We review the evidence supporting adjuvant therapy in early-stage NSCLC; we discuss new issues surrounding adjuvant therapy such as treatment in the elderly-unfit population, treatment toxicity and its influence on outcomes, the importance of histology and gender in adjuvant treatment; and we discuss the future landscape of early-stage NSCLC research, namely, therapeutic strategies exploiting pharmacogenomic and gene-expression profiling, in an attempt to customize the treatment. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：375 / 386

页数：12

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