Inflammation in Obesity-Related Complications in Children: The Protective Effect of Diet and Its Potential Role as a Therapeutic Agent

被引：56

作者：

Calcaterra, Valeria ^{[1
,2
]}

Regalbuto, Corrado ^{[3
,4
]}

Porri, Debora ^{[5
]}

Pelizzo, Gloria ^{[6
,7
]}

Mazzon, Emanuela ^{[8
]}

Vinci, Federica ^{[3
,4
]}

Zuccotti, Gianvincenzo ^{[2
,6
]}

Fabiano, Valentina ^{[2
,6
]}

Cena, Hellas ^{[5
,9
]}

机构：

[1] Univ Pavia, Dept Internal Med, Pediat & Adolescent Unit, Pavia, Italy

[2] V Buzzi Childrens Hosp, Pediat Unit, I-20153 Milan, Italy

[3] Fond IRCCS Policlin S Matteo, Pediat Unit, I-27100 Pavia, Italy

[4] Univ Pavia, I-27100 Pavia, Italy

[5] Univ Pavia, Dept Publ Hlth Expt & Forens Med, Lab Dietet & Clin Nutr, I-27100 Pavia, Italy

[6] Univ Milan, L Sacco Dept Biomed & Clin Sci, I-20153 Milan, Italy

[7] V Buzzi Childrens Hosp, Pediat Surg Unit, I-20153 Milan, Italy

[8] IRCCS Ctr Neurolesi Bonino Pulejo, I-98124 Messina, Italy

[9] ICS Maugeri IRCCS, Unit Internal Med & Endocrinol, Clin Nutr & Dietet Serv, I-27100 Pavia, Italy

来源：

BIOMOLECULES | 2020年 / 10卷 / 09期

关键词：

obesity; children; nutrients; diet; inflammation; prevention; complications; 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; IDIOPATHIC INTRACRANIAL HYPERTENSION; ADIPOSE-TISSUE; CHILDHOOD OBESITY; ASTHMA CONTROL; FATTY-ACIDS; RISK-FACTORS; BODY-FAT; METABOLIC DYSREGULATION; INSULIN SENSITIVITY;

D O I：

10.3390/biom10091324

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Obesity is a growing health problem in both children and adults, impairing physical and mental state and impacting health care system costs in both developed and developing countries. It is well-known that individuals with excessive weight gain frequently develop obesity-related complications, which are mainly known as Non-Communicable Diseases (NCDs), including cardiovascular disease, type 2 diabetes mellitus, metabolic syndrome, non-alcoholic fatty liver disease, hypertension, hyperlipidemia and many other risk factors proven to be associated with chronic inflammation, causing disability and reduced life expectancy. This review aims to present and discuss complications related to inflammation in pediatric obesity, the critical role of nutrition and diet in obesity-comorbidity prevention and treatment, and the impact of lifestyle. Appropriate early dietary intervention for the management of pediatric overweight and obesity is recommended for overall healthy growth and prevention of comorbidities in adulthood.

引用

页码：1 / 18

页数：18