The Renin-Angiotensin-Aldosterone System: Approaches to Guide Angiotensin-Converting Enzyme Inhibition in Patients with Coronary Artery Disease

被引：25

作者：

Brugts, J. J. ^{[1
]}

den Uil, C. A. ^{[1
]}

Danser, A. H. J. ^{[2
]}

Boersma, E. ^{[1
]}

机构：

[1] Erasmus MC, Dept Cardiol, Thoraxctr, NL-3015 CE Rotterdam, Netherlands

[2] Erasmus MC, Dept Pharmacol, NL-3015 CE Rotterdam, Netherlands

来源：

CARDIOLOGY | 2009年 / 112卷 / 04期

关键词：

Angiotensin-converting enzyme inhibitors; Angiotensin; Coronary artery disease; Pharmacogenetics; Prevention; RECEPTOR GENE POLYMORPHISMS; ISCHEMIC-HEART-DISEASE; MAJOR RISK-FACTOR; MYOCARDIAL-INFARCTION; INSERTION/DELETION POLYMORPHISM; CARDIOVASCULAR-DISEASE; DELETION POLYMORPHISM; ACE-INHIBITORS; BLOOD-PRESSURE; PLASMA ANGIOTENSINOGEN;

D O I：

10.1159/000159124

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Drugs that modulate the renin-angiotensin-aldosterone system (RAAS) play an important role in modern cardiovascular prevention strategies. Inhibitors of the RAAS, in particular angiotensin-converting enzyme (ACE) inhibitors, have been proven to be beneficial in specific patient groups, including patients with hypertension, heart failure, diabetes mellitus and stable coronary artery disease. Although clinical trials demonstrated a rather consistent beneficial effect of ACE inhibitors across groups of patients based on clinical characteristics, the variability in treatment response on the individual patient level is extensive. Recent publications suggest that genetic polymorphisms in the RAAS are related to cardiovascular risk. Genetic variability also seems associated with the response to ACE inhibitor therapy, and can probably be used to tailor treatment. This review discusses several approaches to guide ACE inhibitor therapy in patients with coronary artery disease. In addition, the potential impact of pharmacogenetics regarding this particular topic is highlighted. Copyright (C) 2008 S. Karger AG, Basel

引用

页码：303 / 312

页数：10

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