Highly Enantioselective Friedel-Crafts Alkylation/N-Hemiacetalization Cascade Reaction with Indoles

被引：156

作者：

Cheng, Hong-Gang ^{[1
]}

Lu, Liang-Qiu ^{[1
]}

Wang, Tao ^{[1
]}

Yang, Qing-Qing ^{[1
]}

Liu, Xiao-Peng ^{[1
]}

Li, Yang ^{[1
]}

Deng, Qiao-Hui ^{[1
]}

Chen, Jia-Rong ^{[1
]}

Xiao, Wen-Jing ^{[1
,2
]}

机构：

[1] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China

[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 11期

基金：

美国国家科学基金会;

关键词：

alkylation; asymmetric catalysis; chiral Lewis acids; heterocycles; indoles; BETA; GAMMA-UNSATURATED ALPHA-KETOESTERS; ALLYLIC ALKYLATION; PHOSPHORIC-ACID; N-ALLYLATION; CYCLIZATION; CONSTRUCTION; PYRROLOINDOLINES; HYDROARYLATION; CATALYSIS; MICHAEL;

D O I：

10.1002/anie.201209998

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new ring for your indole: An unprecedented copper-catalyzed enantioselective Friedel-Crafts alkylation/N-hemiacetalization cascade reaction with indoles and β,γ-unsaturated α-ketoesters is reported. This mild strategy provides new access to various synthetically and biologically important 2,3-dihydro-1H-pyrrolo[1,2-a]indoles in a highly enantioselective manner. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：3250 / 3254

页数：5

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