The role of IFN-γ production during retroviral infections: an important cytokine involved in chronic inflammation and pathogenesis

被引：0
|
作者：
Soares Cordeiro, Patricia Azevedo [1 ]
Assone, Tatiane [1 ]
Prates, Gabriela [1 ]
Martinez Tedeschi, Marcia Regina [1 ]
Marcondes Fonseca, Luiz Augusto [1 ]
Casseb, Jorge [1 ]
机构：
[1] Univ Sao Paulo, Inst Med Trop Sao Paulo, Lab Invest Dermatol & Imunodeficiencias LIM 56, Fac Med, Sao Paulo, SP, Brazil
来源：
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO | 2022年 / 64卷
关键词：
Retroviruses; HIV; HTLV-1; HERVs; Interferon-gamma; Immune regulation; HUMAN ENDOGENOUS RETROVIRUSES; MULTIPLE-SCLEROSIS; INTERFERON-GAMMA; HTLV-1; INFECTION; HIV-INFECTION; EXPRESSION; ALPHA; MECHANISMS; ELEMENTS; HAM/TSP;
D O I：
10.1590/S1678-9946202264064
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Interferon-gamma (IFN-gamma) plays a crucial role in viral infections by preventing viral replication and in the promotion of innate and adaptive immune responses. However, IFN-gamma can exert distinct effects in different persistent viral infections. The long-term overproduction of IFN-gamma in retroviral infections, such as the human immunodeficiency virus (HIV), human T-lymphotropic virus type 1 (HTLV-1), and human endogenous retroviruses (HERVs), resulting in inflammation, may cause neuronal damage. This review is provocative about the role of IFN-gamma during persistent retroviral infections and its relationship with the causation of some neurological disorders that are important for public health.
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页数：9
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