Porphyrin-Based Metal-Organic Frameworks for Biomedical Applications

被引:442
作者
Chen, Jiajie [1 ,2 ]
Zhu, Yufang [1 ,2 ,3 ]
Kaskel, Stefan [4 ]
机构
[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Dingxi Rd, Shanghai 200050, Peoples R China
[2] Univ Shanghai Sci & Technol, Sch Mat Sci & Engn, 516 Jungong Rd, Shanghai 200093, Peoples R China
[3] Huanggang Normal Univ, Coll Chem Engn, Hubei Key Lab Proc & Applicat Catalyt Mat, Huanggang 438000, Hubei, Peoples R China
[4] Tech Univ Dresden, Fachrichtung Chem & Lebensmittelchem, Anorgan Chem 1, Bergstr 66, D-01062 Dresden, Germany
基金
中国国家自然科学基金;
关键词
biosensing; metal-organic frameworks; porphyrins; tumor therapy; ZEOLITIC IMIDAZOLATE FRAMEWORKS; EFFECTIVE PHOTODYNAMIC THERAPY; HIGH-THROUGHPUT SYNTHESIS; SINGLET-OXYGEN; DRUG-DELIVERY; ELECTROCHEMICAL SENSOR; PHOTOTHERMAL THERAPY; PEROXIDASE-LIKE; MOF NANOSHEETS; GRAPHENE OXIDE;
D O I
10.1002/anie.201909880
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Porphyrins and porphyrin derivatives have been widely explored for various applications owing to their excellent photophysical and electrochemical properties. However, inherent shortcomings, such as instability and self-quenching under physiological conditions, limit their biomedical applications. In recent years, metal-organic frameworks (MOFs) have received increasing attention. The construction of porphyrin-based MOFs by introducing porphyrin molecules into MOFs or using porphyrins as organic linkers to form MOFs can combine the unique features of porphyrins and MOFs as well as overcome the limitations of porphyrins. This Review summarizes important synthesis strategies for porphyrin-based MOFs including porphyrin@MOFs, porphyrinic MOFs, and composite porphyrinic MOFs, and highlights recent achievements and progress in the development of porphyrin-based MOFs for biomedical applications in tumor therapy and biosensing. Finally, the challenges and prospects presented by this class of emerging materials for biomedical applications are discussed.
引用
收藏
页码:5010 / 5035
页数:26
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