High-resolution molecular imaging via intravital microscopy: illuminating vascular biology in vivo

被引：19
作者：
Taqueti, Viviany R. [1 ]
Jaffer, Farouc A. [2 ,3 ,4 ]
机构：
[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Cardiovasc, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA
[3] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA
[4] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Wellman Ctr Photomed, Boston, MA USA
来源：
INTEGRATIVE BIOLOGY | 2013年 / 5卷 / 02期
基金：
美国国家卫生研究院;
关键词：
NEAR-INFRARED FLUORESCENCE; CORONARY ATHEROSCLEROTIC PLAQUES; SMOOTH-MUSCLE-CELLS; E-DEFICIENT MICE; APOLIPOPROTEIN-E; THROMBUS FORMATION; MULTIPHOTON MICROSCOPY; ENDOTHELIAL SELECTINS; CATHEPSIN-S; INFLAMMATION;
D O I：
10.1039/c2ib20194a
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Complications of atherosclerosis and thrombosis are leading causes of death worldwide. While experimental investigations have yielded valuable insights into key molecular and cellular phenomena in these diseases of medium-and large-sized vessels, direct visualization of relevant in vivo biological processes has been limited. However, recent developments in molecular imaging technology, specifically fluorescence imaging agents coupled with high-resolution, high-speed intravital microscopy (IVM), are now enabling dynamic and longitudinal investigations into the mechanisms and progression of many vascular diseases. Here we review recent advances in IVM that have provided new in vivo biological insights into atherosclerosis and thrombosis.
引用
收藏
页码：278 / 290
页数：13
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