Management of colorectal cancer: A role for genetics in prevention and treatment?

被引：19

作者：

Sengupta, Neel ^{[1
]}

Gill, Kathryn A. ^{[1
]}

MacFie, Tammie S. ^{[1
]}

Lai, Cecilia S. ^{[1
]}

Suraweera, Nirosha ^{[1
]}

Mcdonald, Sarah ^{[1
]}

Silver, Andrew ^{[1
]}

机构：

[1] Queen Mary Univ London, Barts & London Sch Med & Dent, Inst Cell & Mol Sci, Colorectal Canc Genet Grp, London E1 2AT, England

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2008年 / 204卷 / 07期

关键词：

colorectal cancer; single-nucleotide polymorphism; microsatellite; instability; chromosomal instability;

D O I：

10.1016/j.prp.2008.03.003

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Colorectal cancer remains one of the most common cancers in the Western world and amongst the top three causes of cancer morbidity and death. Cancer is caused by genetic mutations, but currently there is little use of genetic information in the clinic with the exception of establishing germline mutations for the uncommon predisposing syndromes. Rapid advances in technologies allowing high throughput analysis of germline and somatic mutations raises the possibility that genetics will find a major role in the clinic distinguishing individuals at low to high risk of cancer, allowing early intervention and stratification of cancers based on mutational pathways for therapeutic interventions. In the future, this will lead to treatment regimes tailored to the individuals and their tumor. Here, we summarize the genetics underlying colorectal cancer and the future role of genetics in prevention, diagnosis, classification and treatment. (C) 2008 Elsevier GmbH. All rights reserved.

引用

页码：469 / 477

页数：9

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