The Correlation between Microsatellite Instability and the Features of Sporadic Colorectal Cancer in the North Part of Iran

被引：8

作者：

Faghani, Masoumeh ^{[2
]}

Asl, Saba Fakhrieh ^{[1
]}

Mansour-Ghanaei, Fariborz ^{[1
]}

Aminian, Keyvan ^{[1
]}

Tarang, Alireza ^{[3
]}

Seighalani, Ramin ^{[3
]}

Javadi, Azadeh ^{[3
]}

机构：

[1] Guilan Univ Med Sci, Gastrointestinal & Liver Dis Res Ctr GLDRC, Razi Hosp, Rasht, Iran

[2] Guilan Univ Med Sci, Cellular & Mol Res Ctr, Fac Med, Rasht, Iran

[3] Agr Biotechnol Res Inst N Reg, Genom & Anim Dept, Rasht, Iran

来源：

GASTROENTEROLOGY RESEARCH AND PRACTICE | 2012年 / 2012卷

关键词：

DNA MISMATCH REPAIR; CARCINOMA; TOLERANCE; GENETICS; SURVIVAL; SURGERY; BAT-25; CELLS;

D O I：

10.1155/2012/756263

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background. The aim of this study was to determine the correlation between MSI and sporadic colorectal cancer in Guilan province, North part of Iran. Materials and Methods. A total of 96 patients who underwent resection for sporadic colorectal cancer in Guilan province were studied. No patients had positive family history of cancers. The frequencies of MSI were analyzed by testing the BAT-26 and BAT-25 markers. Results. MSI analysis revealed that 22.9% of the tumors (22 patients) were microsatellite instability positive and 77.1% (74 patients) were microsatellite instability negative. The highest rate of MSI (40.9%) was found in the rectal region. MSI-H status was seen more frequently in distal tumors (P = 0.04, odds ratio = 3.13, 0.96-10.14). Conclusions. Distal tumor location and MSI may associate with special clinicopathological features. It seems that there may be correlation with underlying genetic and immunologic mechanisms.

引用

页数：6

共 34 条

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