Palladium-catalyzed tandem cyclization of fluorinated imidoyl chlorides with 2-bromophenylboronic acid: Synthesis of 6-fluoroalkyl-phenanthridines

被引：25

作者：

Bao, Yinwei ^{[1
]}

Wang, Zhuo ^{[1
]}

Chen, Chen ^{[1
]}

Zhu, Bolin ^{[1
]}

Wang, Yuebo ^{[1
]}

Zhao, Jinghui ^{[1
]}

Gong, Jinyu ^{[1
]}

Han, Mengya ^{[1
]}

Liu, Chang ^{[1
]}

机构：

[1] Tianjin Normal Univ, Coll Chem, Tianjin Key Lab Struct & Performance Funct Mol, MOE Key Lab Inorgan Organ Hybrid Funct Mat Chem, Tianjin 300387, Peoples R China

来源：

TETRAHEDRON | 2019年 / 75卷 / 10期

关键词：

Palladium; Fluorinated imidoyl chlorides; Tandem cyclization; 6-Fluoroalkyl-phenanthridines; RADICAL FLUOROALKYLATION; COUPLING REACTION; ISOCYANIDES; 6-TRIFLUOROMETHYL-PHENANTHRIDINES; TRIFLUOROMETHYLATION; PHENANTHRIDINES; 6-(TRIFLUOROMETHYL)PHENANTHRIDINES; PERFLUOROALKYLATION; 2-ISOCYANOBIPHENYLS; DIFLUOROALKYLATION;

D O I：

10.1016/j.tet.2019.01.058

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method has been developed to synthesize 6-fluoroalkyl-phenanthridines via the palladium-catalyzed tandem cyclization of fluorinated imidoyl chlorides with 2-bromophenylboronic acid. This methodology facilitates the rapid synthesis of 6-fluoroalkyl-phenanthridines through dual C-C bond formation in an oxidant-free one-pot manner. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页码：1450 / 1456

页数：7

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