Synthesis, structural, conformational and pharmacological study of some carbamates derived from 3-methyl-2,4-dipheny1-3-azabicyclo[3.3.1]nonan-9β-ol

被引：7
作者：
Iriepa, I [1 ]
Gil-Alberdi, B
Gálvez, E
Villasante, FJ
Bellanato, J
Carmona, P
机构：
[1] Univ Alcala de Henares, Dept Quim Organ, Madrid, Spain
[2] CSIC, Inst Estructura Mat, E-28006 Madrid, Spain
来源：
JOURNAL OF MOLECULAR STRUCTURE | 1999年 / 482卷
关键词：
3-methyl-2,4-dipheny1-3-azabicyclo[3.3.1]nonan-9 beta-ol; carbamates; vibrational spectroscopy; NMR spectroscopy;
D O I：
10.1016/S0022-2860(98)00947-8
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A series of benzimidazole and benzothiazole carbamates derived from 3-methyl-2,4-diphenyl-3-azabicyclo[3.3.1]nonan-9 beta-ol were synthesized and studied by IR, Raman, H-1 and C-13 NMR spectroscopy. The compounds studied displayed in CDCl3 solution a preferred flattened chair-chair conformation. IR and H-1 and C-13 NMR data showed the presence of an intramolecular hydrogen bond in the benzimidazole carbamates. Pharmacological assays on mice were drawn to evaluate analgesic activity as well as drug-induced behavioral alterations. (C) 1999 Elsevier Science B.V. All rights reserved.
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收藏
页码：437 / 442
页数：6
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