THYROID IN 2012 Advances in thyroid development, hormone action and neoplasia

被引:1
作者
Chatterjee, V. Krishna K. [1 ]
机构
[1] Univ Cambridge, Addenbrookes Hosp, Inst Metab Sci, Cambridge CB2 0QQ, England
基金
英国惠康基金;
关键词
AUTOPHAGY; MUTATION; NODULES; GENE;
D O I
10.1038/nrendo.2012.253
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In 2012, we learned that functional thyroid tissue can be generated in vitro, and that thyroid hormones stimulate autophagy. Patients with defects in TR alpha have been identified, and di-iodothyropropionic acid has been shown to ameliorate MCT8 deficiency. Finally, we found that gene expression profiling can identify benign thyroid nodules. Chatterjee, V. K. K. Nat. Rev. Endocrinol. 9, 74-76 (2013); published online 8 January 2013; doi:10.1038/nrendo.2012.253
引用
收藏
页码:74 / 76
页数:3
相关论文
共 10 条
[1]   Preoperative Diagnosis of Benign Thyroid Nodules with Indeterminate Cytology [J].
Alexander, Erik K. ;
Kennedy, Giulia C. ;
Baloch, Zubair W. ;
Cibas, Edmund S. ;
Chudova, Darya ;
Diggans, James ;
Friedman, Lyssa ;
Kloos, Richard T. ;
LiVolsi, Virginia A. ;
Mandel, Susan J. ;
Raab, Stephen S. ;
Rosai, Juan ;
Steward, David L. ;
Walsh, P. Sean ;
Wilde, Jonathan I. ;
Zeiger, Martha A. ;
Lanman, Richard B. ;
Haugen, Bryan R. .
NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (08) :705-715
[2]   Generation of functional thyroid from embryonic stem cells [J].
Antonica, Francesco ;
Kasprzyk, Dominika Figini ;
Opitz, Robert ;
Iacovino, Michelina ;
Liao, Xiao-Hui ;
Dumitrescu, Alexandra Mihaela ;
Refetoff, Samuel ;
Peremans, Kathelijne ;
Manto, Mario ;
Kyba, Michael ;
Costagliola, Sabine .
NATURE, 2012, 491 (7422) :66-U170
[3]   A Mutation in the Thyroid Hormone Receptor Alpha Gene [J].
Bochukova, Elena ;
Schoenmakers, Nadia ;
Agostini, Maura ;
Schoenmakers, Erik ;
Rajanayagam, Odelia ;
Keogh, Julia M. ;
Henning, Elana ;
Reinemund, Jana ;
Gevers, Evelien ;
Sarri, Margarita ;
Downes, Kate ;
Offiah, Amaka ;
Albanese, Assunta ;
Halsall, David ;
Schwabe, John W. R. ;
Bain, Murray ;
Lindley, Keith ;
Muntoni, Francesco ;
Khadem, Faraneh Vargha ;
Dattani, Mehul ;
Farooqi, I. Sadaf ;
Gurnell, Mark ;
Chatterjee, Krishna .
NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (03) :243-249
[4]   The Impact of Benign Gene Expression Classifier Test Results on the Endocrinologist-Patient Decision to Operate on Patients with Thyroid Nodules with Indeterminate Fine-Needle Aspiration Cytopathology [J].
Duick, Daniel S. ;
Klopper, Joshua P. ;
Diggans, James C. ;
Friedman, Lyssa ;
Kennedy, Giulia C. ;
Lanman, Richard B. ;
McIver, Bryan .
THYROID, 2012, 22 (10) :996-1001
[5]   Autophagy regulates lipid metabolism [J].
Singh, Rajat ;
Kaushik, Susmita ;
Wang, Yongjun ;
Xiang, Youqing ;
Novak, Inna ;
Komatsu, Masaaki ;
Tanaka, Keiji ;
Cuervo, Ana Maria ;
Czaja, Mark J. .
NATURE, 2009, 458 (7242) :1131-U64
[6]   Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy [J].
Sinha, Rohit Anthony ;
You, Seo-Hee ;
Zhou, Jin ;
Siddique, Mobin M. ;
Bay, Boon-Huat ;
Zhu, Xuguang ;
Privalsky, Martin L. ;
Cheng, Sheue-Yann ;
Stevens, Robert D. ;
Summers, Scott A. ;
Newgard, Christopher B. ;
Lazar, Mitchell A. ;
Yen, Paul M. .
JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (07) :2428-2438
[7]   Self-formation of functional adenohypophysis in three-dimensional culture [J].
Suga, Hidetaka ;
Kadoshima, Taisuke ;
Minaguchi, Maki ;
Ohgushi, Masatoshi ;
Soen, Mika ;
Nakano, Tokushige ;
Takata, Nozomu ;
Wataya, Takafumi ;
Muguruma, Keiko ;
Miyoshi, Hiroyuki ;
Yonemura, Shigenobu ;
Oiso, Yutaka ;
Sasai, Yoshiki .
NATURE, 2011, 480 (7375) :57-U215
[8]   Clinical Phenotype and Mutant TRα1 [J].
van Mullem, Alies ;
van Heerebeek, Ramona ;
Chrysis, Dionisios ;
Visser, Edward ;
Medici, Marco ;
Andrikoula, Maria ;
Tsatsoulis, Agathocles ;
Peeters, Robin ;
Visser, Theo J. .
NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (15) :1451-1453
[9]   Severe psychomotor and metabolic damages caused by a mutant thyroid hormone receptor alpha 1 in mice: can patients with a similar mutation be found and treated? [J].
Vennstrom, Bjorn ;
Mittag, Jens ;
Wallis, Karin .
ACTA PAEDIATRICA, 2008, 97 (12) :1605-1610
[10]   Diiodothyropropionic Acid (DITPA) in the Treatment of MCT8 Deficiency [J].
Verge, Charles F. ;
Konrad, Daniel ;
Cohen, Michal ;
Di Cosmo, Caterina ;
Dumitrescu, Alexandra M. ;
Marcinkowski, Teresa ;
Hameed, Shihab ;
Hamilton, Jill ;
Weiss, Roy E. ;
Refetoff, Samuel .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2012, 97 (12) :4515-4523