Relapse of inflammatory bowel disease associated with use of nonsteroidal anti-inflammatory drugs

被引:48
作者
Meyer, AM [1 ]
Ramzan, NN [1 ]
Heigh, RI [1 ]
Leighton, JA [1 ]
机构
[1] Mayo Clin, Div Gastroenterol & Hepatol, Scottsdale, AZ 85259 USA
关键词
Crohn's disease; colitis; ulcerative; inflammatory bowel disease; nonsteroidal anti-inflammatory drugs;
D O I
10.1007/s10620-006-3103-5
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
To determine whether an association exists between relapse in inflammatory bowel disease and use of nonsteroidal anti-inflammatory drugs (NSAIDs), a retrospective records review was conducted of patients with Crohn's disease, ulcerative colitis, or indeterminate colitis examined at an outpatient tertiary care center between July 17, 2000, and November 1, 2001. Extracted data collected during the patient's last visit included medication use, maintenance therapy, disease activity, and smoking status. Use of NSAIDs was defined as a daily dose or more of any type the month before relapse. Of 60 patients (22, relapse; 38, remission), 9 (41%) in relapse and 10 (26%) in remission used NSAIDs. Maintenance therapy varied from 68% (relapse) to 92% (remission). The adjusted odds ratio between medication use and relapse was 6.31 (95% confidence interval, 1.16-34.38; P = .03). Use of NSAIDs was associated with relapse. A prospective cohort study that corrects for maintenance therapy is needed to evaluate this relationship.
引用
收藏
页码:168 / 172
页数:5
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