Control of fed-batch fermentations

被引：231
作者：
Lee, J
Lee, SY
Park, S
Middelberg, APJ
机构：
[1] Korea Adv Inst Sci & Technol, Dept Chem Engn, Taejon 305701, South Korea
[2] Univ Adelaide, Dept Chem Engn, Adelaide, SA 5005, Australia
来源：
BIOTECHNOLOGY ADVANCES | 1999年 / 17卷 / 01期
关键词：
fed-batch fermentation; exponential feeding; fuzzy control; neural networks;
D O I：
10.1016/S0734-9750(98)00015-9
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Fed-batch fermentation is used to prevent or reduce substrate-associated growth inhibition by controlling nutrient supply. Here we review the advances in control of fed-batch fermentations. Simple exponential feeding and inferential methods are examined, as are newer methods based on fuzzy control and neural networks. Considerable interest has developed in these more advanced methods that hold promise for optimizing fed-batch techniques for complex fermentation systems. (C) 1999 Elsevier Science Inc. All rights reserved.
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页码：29 / 48
页数：20
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