Are oxidative stress and mitochondrial dysfunction the key players in the neurodegenerative diseases?

被引：95
作者：
Di Carlo, Marta [1 ]
Giacomazza, Daniela [2 ]
Picone, Pasquale [1 ]
Nuzzo, Domenico [1 ]
San Biagio, Pier Luigi [2 ]
机构：
[1] CNR, IBIM, I-90146 Palermo, Italy
[2] CNR, Ist Biofis IBF, I-90146 Palermo, Italy
来源：
FREE RADICAL RESEARCH | 2012年 / 46卷 / 11期
关键词：
Alzheimer's disease; Parkinson's disease; amyotrophic lateral sclerosis; proteomics; miRNA; epigenetics; AMYOTROPHIC-LATERAL-SCLEROSIS; FREE-RADICAL THEORY; SUPEROXIDE-DISMUTASE ACTIVITY; MILD COGNITIVE IMPAIRMENT; AMYLOID PRECURSOR PROTEIN; MOTOR-NEURON DEGENERATION; G93A-SOD1 TRANSGENIC MICE; AGE-RELATED-CHANGES; ALZHEIMERS-DISEASE; A-BETA;
D O I：
10.3109/10715762.2012.714466
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Oxidative stress has long been linked to neuronal cell death that is associated with certain neurodegenerative conditions. Whether it is a primary cause or merely a downstream consequence of the neurodegenerative and aging process is still an open question. Mitochondria are deeply involved in the production of reactive oxygen species through the electron carriers of the respiratory chain and their role in neurodegenerative diseases is discussed here. Moreover, the input of new technological approaches in the study of oxidative stress response or in the evidence of an oxidative stress component in neurodegeneration is reviewed in this paper.
引用
收藏
页码：1327 / 1338
页数：12
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