Selective RNA Versus DNA G-Quadruplex Targeting by In Situ Click Chemistry

被引：149

作者：

Di Antonio, Marco ^{[1
]}

Biffi, Giulia ^{[2
]}

Mariani, Angelica ^{[1
]}

Raiber, Eun-Ang ^{[1
]}

Rodriguez, Raphael ^{[1
]}

Balasubramanian, Shankar ^{[1
,2
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[2] Canc Res UK, Li Ka Shing Ctr, Cambridge Res Inst, Cambridge CB2 0RE, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 44期

基金：

英国生物技术与生命科学研究理事会;

关键词：

click chemistry; DNA; G-quadruplexes; RNA; telomeres; SMALL-MOLECULE; INHIBITORS; BINDING; LIGAND; ACETYLCHOLINESTERASE; CYCLOADDITION; GENERATION; SHELTERIN; ALKYNES; TERRA;

D O I：

10.1002/anie.201206281

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

It all clicks into place: A potent telomere-targeting small molecule has been identified by using the copper-free 1,3-dipolar cycloaddition of a series of alkyne and azide building blocks catalyzed by a non-Watson-Crick DNA secondary structure (see picture). This method rapidly identifies, otherwise unanticipated, potent small-molecule probes to selectively target a given RNA or DNA. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：11073 / 11078

页数：6

共 62 条

[1]

Agnew H. D., 2009, ANGEW CHEM, V121, P5044

[2] Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution [J].

Ambrus, Attila ;

Chen, Ding ;

Dai, Jixun ;

Bialis, Tiffanie ;

Jones, Roger A. ;

Yang, Danzhou .

NUCLEIC ACIDS RESEARCH, 2006, 34 (09) :2723-2735

[3]

[Anonymous], 2001, ANGEW CHEM, V113, P1824

[4] Telomeric repeat-containing RNA and RNA surveillance factors at mammalian chromosome ends [J].

Azzalin, Claus M. ;

Reichenbach, Patrick ;

Khoriauli, Lela ;

Giulotto, Elena ;

Lingner, Joachim .

SCIENCE, 2007, 318 (5851) :798-801

[5] Copper-free click chemistry for dynamic in vivo imaging [J].

Baskin, Jeremy M. ;

Prescher, Jennifer A. ;

Laughlin, Scott T. ;

Agard, Nicholas J. ;

Chang, Pamela V. ;

Miller, Isaac A. ;

Lo, Anderson ;

Codelli, Julian A. ;

Bertozzi, Carolyn R. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (43) :16793-16797

[6]

Bugaut A., 2008, ANGEW CHEM INT EDIT, V120, P2717

[7] Exploring the differential recognition of DNA G-quadruplex targets by small molecules using dynamic combinatorial chemistry [J].

Bugaut, Anthony ;

Jantos, Katja ;

Wietor, Jean-Luc ;

Rodriguez, Raphael ;

Sanders, Jeremy K. M. ;

Balasubramanian, Shankar .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2008, 47 (14) :2677-2680

[8] Copper-free click chemistry in living animals [J].

Chang, Pamela V. ;

Prescher, Jennifer A. ;

Sletten, Ellen M. ;

Baskin, Jeremy M. ;

Miller, Isaac A. ;

Agard, Nicholas J. ;

Lo, Anderson ;

Bertozzi, Carolyn R. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (05) :1821-1826

[9] A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex [J].

Collie, Gavin W. ;

Haider, Shozeb M. ;

Neidle, Stephen ;

Parkinson, Gary N. .

NUCLEIC ACIDS RESEARCH, 2010, 38 (16) :5569-5580

[10] Shelterin: the protein complex that shapes and safeguards human telomeres [J].

de Lange, T .

GENES & DEVELOPMENT, 2005, 19 (18) :2100-2110

← 1 2 3 4 5 6 7 →