Selective RNA Versus DNA G-Quadruplex Targeting by In Situ Click Chemistry

被引：143
作者：
Di Antonio, Marco [1 ]
Biffi, Giulia [2 ]
Mariani, Angelica [1 ]
Raiber, Eun-Ang [1 ]
Rodriguez, Raphael [1 ]
Balasubramanian, Shankar [1 ,2 ]
机构：
[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England
[2] Canc Res UK, Li Ka Shing Ctr, Cambridge Res Inst, Cambridge CB2 0RE, England
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 44期
基金：
英国生物技术与生命科学研究理事会;
关键词：
click chemistry; DNA; G-quadruplexes; RNA; telomeres; SMALL-MOLECULE; INHIBITORS; BINDING; LIGAND; ACETYLCHOLINESTERASE; CYCLOADDITION; GENERATION; SHELTERIN; ALKYNES; TERRA;
D O I：
10.1002/anie.201206281
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
It all clicks into place: A potent telomere-targeting small molecule has been identified by using the copper-free 1,3-dipolar cycloaddition of a series of alkyne and azide building blocks catalyzed by a non-Watson-Crick DNA secondary structure (see picture). This method rapidly identifies, otherwise unanticipated, potent small-molecule probes to selectively target a given RNA or DNA. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：11073 / 11078
页数：6
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