New 1-indanone thiosemicarbazone derivatives active against BVDV

被引：89

作者：

Finkielsztein, Liliana M. ^{[1
]}

Castro, Eliana F. ^{[3
]}

Fabian, Lucas E. ^{[2
]}

Moltrasio, Graciela Y. ^{[1
]}

Campos, Rodolfo H. ^{[3
]}

Cavallaro, Lucia V. ^{[3
]}

Moglioni, Albertina G. ^{[2
]}

机构：

[1] Univ Buenos Aires, Fac Farm & Bioquim, Catedra Quim Organ 3, RA-1113 Buenos Aires, DF, Argentina

[2] Univ Buenos Aires, Fac Farm & Bioquim, Catedra Quim Med, RA-1113 Buenos Aires, DF, Argentina

[3] Univ Buenos Aires, Fac Farm & Bioquim, Catedra Virol, RA-1113 Buenos Aires, DF, Argentina

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2008年 / 43卷 / 08期

关键词：

thiosemicarbazones derived from 1-indanones; antiviral activity;

D O I：

10.1016/j.ejmech.2007.10.023

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Identification of new therapeutic agents for the treatment of viral diseases represents an area of active investigation. In an effort to develop new antiviral compounds, a series of 1-indanone thiosemicarbazone derivatives were synthesized. These derivatives were structurally characterized using several spectroscopic techniques and evaluated against bovine viral diarrhoea virus as a surrogate model for hepatitis C virus. Thiosemicarbazone 2m showed potent anti-bovine viral diarrhoea virus activity with a higher selectivity index (SI = 80.29) than that of ribavirin (SI = 11.64). This result determines the potentiality of these thiosemicarbazones as antiviral agents for the treatment of infections caused by other highly related members of Flaviviridae family, as hepatitis C virus. (c) 2007 Elsevier Masson SAS. All rights reserved.

引用

页码：1767 / 1773

页数：7

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