GENOTYPING OF-374A/T,-429A/G, AND 63 bp INS/DEL POLYMORPHISMS OF RAGE BY RAPID ONE-STEP HEXAPRIMER AMPLIFICATION REFRACTORY MUTATION SYSTEM POLYMERASE CHAIN REACTION IN BREAST CANCER PATIENTS

被引：19

作者：

Hashemi, Mohammad ^{[1
,2
]}

Moazeni-roodi, Abdolkarim ^{[3
]}

Arbabi, Farshid ^{[4
]}

Fazaeli, Aliakbar ^{[1
]}

Nasab, Ebrahim Eskandari ^{[1
]}

Taheri, Mohsen ^{[2
]}

Kerkhoff, Claus ^{[5
]}

Ghavami, Saeid ^{[6
]}

机构：

[1] Zahedan Univ Med Sci, Dept Clin Biochem, Sch Med, Zahedan, Iran

[2] Zahedan Univ Med Sci, Cellular & Mol Res Ctr, Zahedan, Iran

[3] Zahedan Univ Med Sci, Res Ctr Infect Dis & Trop Med, Zahedan, Iran

[4] Zahedan Univ Med Sci, Dept Internal Med, Sch Med, Zahedan, Iran

[5] Dept Internal Med, Div Gastroenterol, Rostock, Germany

[6] Univ Manitoba, Dept Physiol, Manitoba Inst Child Hlth, Winnipeg, MB, Canada

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2012年 / 31卷 / 05期

关键词：

Breast cancer; RAGE; polymorphism; GLYCATION END-PRODUCTS; CELL-SURFACE RECEPTOR; GENE POLYMORPHISMS; SOLUBLE RECEPTOR; S100A8/A9; BINDING; ASSOCIATION; ACTIVATION; EXPRESSION; ARTHRITIS;

D O I：

10.1080/15257770.2012.665545

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several studies have focused on the RAGE genetic background and have demonstrated that its polymorphisms affect the receptor's activity, expression, and downstream signaling. However, there is only little information regarding RAGE polymorphism in breast cancer. In the present study, the authors studied RAGE polymorphisms in 71 patients with breast cancer and 93 healthy women. RAGE-374T/A, -429T/C, and 63 bp Ins/del polymorphisms were analyzed using a hexaprimer amplification refractory mutation system PCR (H-ARMS-PCR). The results showed that RAGE polymorphisms are not associated with breast cancer in the current study population. Larger studies are required to confirm these data in other populations.

引用

页码：401 / 410

页数：10

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