Zein nanoparticles improve the oral bioavailability of resveratrol in humans

被引：25

作者：

Brotons-Canto, Ana ^{[1
]}

Gonzalez-Navarro, Carlos Javier ^{[2
]}

Gurrea, Javier ^{[3
]}

Gonzalez-Ferrero, Carolina ^{[4
]}

Irache, Juan Manuel ^{[5
]}

机构：

[1] Nucaps Nanotechnol SL, Noain 31110, Spain

[2] Univ Navarra, Ctr Nutr Res, Pamplona 31008, Spain

[3] Idifarma Desarrollo Farmaceut SL, Noain 31110, Spain

[4] CNTA, Natl Ctr Food Technol & Safety, San Adrian 31570, Spain

[5] Univ Navarra, NANO VAC Res Grp, Dept Chem & Pharmaceut Technol, Pamplona 31008, Spain

来源：

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2020年 / 57卷

关键词：

TRANS-RESVERATROL; HEALTHY-VOLUNTEERS; DELIVERY-SYSTEM; HUMAN PLASMA; MOUSE MODEL; METABOLITES; ABSORPTION; QUERCETIN; GROWTH; RATS;

D O I：

10.1016/j.jddst.2020.101704

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Resveratrol is a polyphenol present on natural products with a wide range of beneficial properties including antioxidant, anti-inflammatory and chemoprotective effects. However, its low water solubility and rapid presystemic metabolism hampers its absorption and systemic bioavailability. This study investigates the potential of a nanoparticle-based system for the oral delivery of resveratrol in humans and its impact on pharmacokinetics. Resveratrol-loaded zein nanoparticles were prepared and characterized prior to its administration to humans. These nanoparticles displayed a mean size of 331 nm with an encapsulation efficiency of 87%. A single dose of 250 mg of resveratrol was administered to 16 healthy volunteers and the concentrations of resveratrol and its metabolite resveratrol-3-0-D-glucuronide were estimated. The formulation was well tolerated and showed quantifiable plasma levels of resveratrol and its metabolite (Cmax 21.80 and 986.29 ng/mL, respectively). Therefore, this nanoparticle-based formulation has shown a great potential as a nutraceutical for the oral administration of resveratrol. © 2020 Elsevier B.V.

引用

页数：7

共 66 条

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