Human Genetic and Structural Genomic Variation: Would Genome-Wide Association Studies Be the Solution for Cancer Complexity Like Alexander the Great for the "Gordian Knot"?

被引：63

作者：

Roukos, Dimitrios H. ^{[1
]}

Ziogas, Dimosthenis ^{[1
]}

机构：

[1] Univ Ioannina, Sch Med, Dept Surg, Surg Oncol Res Unit, GR-45110 Ioannina, Greece

来源：

ANNALS OF SURGICAL ONCOLOGY | 2009年 / 16卷 / 03期

关键词：

BREAST-CANCER; PERSONALIZED TREATMENT; GASTRIC-CANCER; MANAGEMENT; RISK;

D O I：

10.1245/s10434-008-0056-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：774 / 775

页数：2

共 18 条

[1] Models, mechanisms and clinical evidence for cancer dormancy [J].

Aguirre-Ghiso, Julio A. .

NATURE REVIEWS CANCER, 2007, 7 (11) :834-846

[2] The genomic heritage of lymph node metastases: Implications for clinical management of patients with breast cancer [J].

Becker, Tyson E. ;

Ellsworth, Rachel E. ;

Deyarmin, Brenda ;

Patney, Heather L. ;

Jordan, Rick M. ;

Hooke, Jeffrey A. ;

Shriver, Craig D. ;

Ellsworth, Darrell L. .

ANNALS OF SURGICAL ONCOLOGY, 2008, 15 (04) :1056-1063

[3] Genome-wide association study identifies novel breast cancer susceptibility loci [J].

Easton, Douglas F. ;

Pooley, Karen A. ;

Dunning, Alison M. ;

Pharoah, Paul D. P. ;

Thompson, Deborah ;

Ballinger, Dennis G. ;

Struewing, Jeffery P. ;

Morrison, Jonathan ;

Field, Helen ;

Luben, Robert ;

Wareham, Nicholas ;

Ahmed, Shahana ;

Healey, Catherine S. ;

Bowman, Richard ;

Meyer, Kerstin B. ;

Haiman, Christopher A. ;

Kolonel, Laurence K. ;

Henderson, Brian E. ;

Le Marchand, Loic ;

Brennan, Paul ;

Sangrajrang, Suleeporn ;

Gaborieau, Valerie ;

Odefrey, Fabrice ;

Shen, Chen-Yang ;

Wu, Pei-Ei ;

Wang, Hui-Chun ;

Eccles, Diana ;

Evans, D. Gareth ;

Peto, Julian ;

Fletcher, Olivia ;

Johnson, Nichola ;

Seal, Sheila ;

Stratton, Michael R. ;

Rahman, Nazneen ;

Chenevix-Trench, Georgia ;

Bojesen, Stig E. ;

Nordestgaard, Borge G. ;

Axelsson, Christen K. ;

Garcia-Closas, Montserrat ;

Brinton, Louise ;

Chanock, Stephen ;

Lissowska, Jolanta ;

Peplonska, Beata ;

Nevanlinna, Heli ;

Fagerholm, Rainer ;

Eerola, Hannaleena ;

Kang, Daehee ;

Yoo, Keun-Young ;

Noh, Dong-Young ;

Ahn, Sei-Hyun .

NATURE, 2007, 447 (7148) :1087-U7

[4] A second generation human haplotype map of over 3.1 million SNPs [J].

Frazer, Kelly A. ;

Ballinger, Dennis G. ;

Cox, David R. ;

Hinds, David A. ;

Stuve, Laura L. ;

Gibbs, Richard A. ;

Belmont, John W. ;

Boudreau, Andrew ;

Hardenbol, Paul ;

Leal, Suzanne M. ;

Pasternak, Shiran ;

Wheeler, David A. ;

Willis, Thomas D. ;

Yu, Fuli ;

Yang, Huanming ;

Zeng, Changqing ;

Gao, Yang ;

Hu, Haoran ;

Hu, Weitao ;

Li, Chaohua ;

Lin, Wei ;

Liu, Siqi ;

Pan, Hao ;

Tang, Xiaoli ;

Wang, Jian ;

Wang, Wei ;

Yu, Jun ;

Zhang, Bo ;

Zhang, Qingrun ;

Zhao, Hongbin ;

Zhao, Hui ;

Zhou, Jun ;

Gabriel, Stacey B. ;

Barry, Rachel ;

Blumenstiel, Brendan ;

Camargo, Amy ;

Defelice, Matthew ;

Faggart, Maura ;

Goyette, Mary ;

Gupta, Supriya ;

Moore, Jamie ;

Nguyen, Huy ;

Onofrio, Robert C. ;

Parkin, Melissa ;

Roy, Jessica ;

Stahl, Erich ;

Winchester, Ellen ;

Ziaugra, Liuda ;

Altshuler, David ;

Shen, Yan .

NATURE, 2007, 449 (7164) :851-U3

[5] Genetic screening for signal transduction in the era of network biology [J].

Friedman, Adam ;

Perrimon, Norbert .

CELL, 2007, 128 (02) :225-231

[6] Genome-wide association study provides evidence for a breast cancer risk locus at 6q22-33 [J].

Gold, Bert ;

Kirchhoff, Tomas ;

Stefanov, Stefan ;

Lautenberger, James ;

Viale, Agnes ;

Garber, Judy ;

Friedman, Eitan ;

Narod, Steven ;

Olshen, Adam B. ;

Gregersen, Peter ;

Kosarin, Kristi ;

Olsh, Adam ;

Bergeron, Julie ;

Ellis, Nathan A. ;

Klein, Robert J. ;

Clark, Andrew G. ;

Norton, Larry ;

Dean, Michael ;

Boyd, Jeff ;

Offit, Kenneth .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (11) :4340-4345

[7] Letting the genome out of the bottle - Will we get our wish? [J].

Hunter, David J. ;

Khoury, Muin J. ;

Drazen, Jeffrey M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (02) :105-107

[8] A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer [J].

Hunter, David J. ;

Kraft, Peter ;

Jacobs, Kevin B. ;

Cox, David G. ;

Yeager, Meredith ;

Hankinson, Susan E. ;

Wacholder, Sholom ;

Wang, Zhaoming ;

Welch, Robert ;

Hutchinson, Amy ;

Wang, Junwen ;

Yu, Kai ;

Chatterjee, Nilanjan ;

Orr, Nick ;

Willett, Walter C. ;

Colditz, Graham A. ;

Ziegler, Regina G. ;

Berg, Christine D. ;

Buys, Saundra S. ;

McCarty, Catherine A. ;

Feigelson, Heather Spencer ;

Calle, Eugenia E. ;

Thun, Michael J. ;

Hayes, Richard B. ;

Tucker, Margaret ;

Gerhard, Daniela S. ;

Fraumeni, Joseph F., Jr. ;

Hoover, Robert N. ;

Thomas, Gilles ;

Chanock, Stephen J. .

NATURE GENETICS, 2007, 39 (07) :870-874

[9] Structural genomic variation and personalized medicine [J].

Lee, Charles ;

Morton, Cynthia C. .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (07) :740-741

[10] More controversy than ever - Challenges and promises towards personalized treatment of gastric cancer [J].

Liakakos, Theodore ;

Roukos, Dimitrios H. .

ANNALS OF SURGICAL ONCOLOGY, 2008, 15 (04) :956-960

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