Suppressive Effects of Carotenoids on the Antigen-induced Degranulation in RBL-2H3 Rat Basophilic Leukemia Cells

被引：29

作者：

Manabe, Yuki ^{[1
]}

Hirata, Takashi ^{[1
,2
]}

Sugawara, Tatsuya ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Agr, Div Appl Biosci, Sakyo Ku, Kyoto 6068502, Japan

[2] Shijonawate Gakuen Univ, Daito, Osaka 5740011, Japan

来源：

JOURNAL OF OLEO SCIENCE | 2014年 / 63卷 / 03期

关键词：

carotenoid; degranulation; mast cell; type I allergy; FUCOXANTHINOL;

D O I：

10.5650/jos.ess13169

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In this study, the anti-degranulation effects of fifteen carotenoids were evaluated using RBL-2113 rat basophilic leukemia cell line as a mast cell model. Nine carotenoids, fucoxanthin, zeaxanthin, beta-carotene, astaxanthin, 3-hydroxyechinenone, fucoxanthinol, lycopene, beta-cryptoxanthin, and siphonaxanthin significantly suppressed antigen-induced mast cell degranulation. Under the same conditions, the cellular carotenoid contents were quantified using high performance liquid chromatography-photodiode array (HPLC-PDA). There was no correlation between the cellular carotenoid contents and their antidegranulation activities. These results indicate that the differences in the anti-degranulation activities of carotenoids were not related to their uptake by the cells.

引用

页码：291 / 294

页数：4

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