Gene transcription in the zebrafish embryo: regulators and networks

被引：12

作者：

Ferg, Marco ^{[1
]}

Armant, Olivier ^{[1
]}

Yang, Lixin ^{[1
]}

Dickmeis, Thomas ^{[1
]}

Rastegar, Sepand ^{[1
]}

Straehle, Uwe ^{[1
]}

机构：

[1] Heidelberg Univ, D-69115 Heidelberg, Germany

来源：

BRIEFINGS IN FUNCTIONAL GENOMICS | 2014年 / 13卷 / 02期

关键词：

zebrafish; transcription regulator; gene regulatory network; cis-regulatory element; genomics; CHROMATIN REMODELING COMPLEX; KEY DEVELOPMENTAL GENES; LATERAL FLOOR PLATE; SPINAL-CORD; RNA-POLYMERASE; NUCLEAR REORGANIZATION; SEQUENCE CONSERVATION; HYPERSENSITIVE SITES; ENHANCER ACTIVITY; TARGET GENES;

D O I：

10.1093/bfgp/elt044

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The precise spatial and temporal control of gene expression is a key process in the development, maintenance and regeneration of the vertebrate body. A substantial proportion of vertebrate genomes encode genes that control the transcription of the genetic information into mRNA. The zebrafish is particularly well suited to investigate gene regulatory networks underlying the control of gene expression during development due to the external development of its transparent embryos and the increasingly sophisticated tools for genetic manipulation available for this model system. We review here recent data on the analysis of cis-regulatory modules, transcriptional regulators and their integration into gene regulatory networks in the zebrafish, using the developing spinal cord as example.

引用

页码：131 / 143

页数：13

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