Antiparasitic activity of some xanthones and biflavonoids from the root bark of Garcinia livingstonei

被引：86
作者：
Mbwambo, ZH
Kapingu, MC
Moshi, MJ
Machumi, F
Apers, S
Cos, P
Ferreira, D
Marais, JPJ
Vanden Berghe, D
Maes, L
Vlietinck, A
Pieters, L
机构：
[1] Univ Antwerp, Dept Pharmaceut Sci, Lab Pharmacognosy & Phytochem, B-2610 Antwerp, Belgium
[2] Muhimbili Univ, Coll Hlth Sci, Inst Tradit Med, Dar Es Salaam, Tanzania
[3] Univ Mississippi, Dept Pharmacognosy, Sch Pharm, University, MS 38677 USA
[4] Univ Mississippi, Natl Ctr Nat Prod Res, Sch Pharm, University, MS 38677 USA
[5] Univ Antwerp, Dept Pharmaceut Sci, Lab Microbiol Parasitol & Hyg, B-2020 Antwerp, Belgium
[6] Univ Antwerp, Dept Biomed Sci, B-2020 Antwerp, Belgium
来源：
JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 03期
关键词：
D O I：
10.1021/np050406v
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A new biflavanoid, ent-naringeninyl-(I-3 alpha,II-8)-4'-O-methylnaringenin (6), along with five known xanthones and two known biflavonoids, was isolated from the root bark of Garcinia livingstonei collected in Tanzania. The absolute configuration of 6 was established by CD spectroscopy. This compound showed moderate activity against P. falciparum (IC50 6.7 mu M). Antitrypanosomal activity (IC50 0.87 mu M) was observed for 1,4,5-trihydroxy-3-(3-methylbut-2-enyl)-9H-xanthen-9-one (3). The dimeric xanthone garcilivin A (4) showed a higher and nonselective antiparasitic activity and cytotoxicity (IC50 2.0 mu M against MRC-5 cells) than its diastereoisomer garcilivin C (5) (IC50 52.3 mu M).
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页码：369 / 372
页数：4
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