Amyloid-PET and 18F-FDG-PET in the diagnostic investigation of Alzheimer's disease and other dementias

被引：332

作者：

Chetelat, Gael ^{[1
]}

Arbizu, Javier ^{[2
]}

Barthel, Henryk ^{[3
]}

Garibotto, Valentina ^{[4
,5
]}

Law, Ian ^{[6
]}

Morbelli, Silvia ^{[7
]}

van de Giessen, Elsmarieke ^{[9
]}

Agosta, Federica ^{[12
,13
]}

Barkhof, Frederik ^{[10
,14
,15
]}

Brooks, David J. ^{[18
,19
,20
]}

Carrillo, Maria C. ^{[21
]}

Dubois, Bruno ^{[22
]}

Fjell, Anders M. ^{[23
,24
]}

Frisoni, Giovanni B. ^{[25
,26
]}

Hansson, Oskar ^{[27
,28
]}

Herholz, Karl ^{[29
]}

Hutton, Brian F. ^{[16
]}

Jack, Clifford R., Jr. ^{[30
]}

Lammertsma, Adriaan A. ^{[10
]}

Landau, Susan M. ^{[31
]}

Minoshima, Satoshi ^{[32
]}

Nobili, Flavio ^{[8
,33
]}

Nordberg, Agneta ^{[34
]}

Ossenkoppele, Rik ^{[11
,35
]}

Oyen, Wim J. G. ^{[36
,37
,38
,39
]}

Perani, Daniela ^{[40
]}

Rabinovici, Gil D. ^{[41
,42
,43
]}

Scheltens, Philip ^{[11
]}

Villemagne, Victor L. ^{[44
,45
,46
]}

Zetterberg, Henrik ^{[17
,47
,48
,49
]}

Drzezga, Alexander ^{[50
,51
,52
,53
]}

机构：

[1] Univ Caen, Normandie Univ, INSERM, Unite 1237,Grp Interet Publ Cyceron, F-14074 Caen, France

[2] Univ Navarra, Clin Univ Navarra, Dept Nucl Med, Pamplona, Spain

[3] Univ Hosp Leipzig, Dept Nucl Med, Leipzig, Germany

[4] Univ Geneva, Geneva Univ Hosp, Div Nucl Med & Mol Imaging, Geneva, Switzerland

[5] Univ Geneva, NIMTlab, Geneva, Switzerland

[6] Copenhagen Univ Hosp, Rigshosp, Dept Clin Physiol Nucl Med & PET, Copenhagen, Denmark

[7] Ist Ricovero & Cura Carattere Sci Osped Policlin, Nudear Med Unit, Genoa, Italy

[8] Ist Ricovero & Cura Carattere Sci Osped Policlin, UO Clin Neurolog, Genoa, Italy

[9] Univ Amsterdam, Amsterdam Univ, Med Ctr, Dept Radiol & Nucl Med, Amsterdam, Netherlands

[10] Vrije Univ Amsterdam, Amsterdam Univ, Med Ctr, Dept Radiol & Nudear Med, Amsterdam, Netherlands

[11] Vrije Univ Amsterdam, Amsterdam Univ, Med Ctr, Dept Neurol,Alzheimer Ctr, Amsterdam, Netherlands

[12] Ist Sci San Raffaele, Ist Ricovero & Cura Carattere, Inst Expt Neurol, Div Neurosci, Milan, Italy

[13] Univ Vita Salute San Raffaele, Milan, Italy

[14] UCL, Inst Neurol, London, England

[15] UCL, Inst Healthcare Engn, London, England

[16] UCL, Inst Nucl Med, London, England

[17] UCL, Inst Neurol, Dept Neurodegenerat Dis, London, England

[18] Newcastle Univ, Inst Neurosci, Newcastle, England

[19] Aarhus Univ Hosp, Dept Nucl Med, Aarhus, Denmark

[20] Aarhus Univ Hosp, PET Ctr, Aarhus, Denmark

[21] Alzheimers Assoc, Chicago, IL USA

[22] Sorbonne Univ, Univ Hosp Pitie Salpetriere, AP HP, Ctr Malad Cognit & Comportementales, Paris, France

[23] Univ Oslo, Ctr Lifespan Changes Brain & Cognit, Dept Psychol, Oslo, Norway

[24] Oslo Univ Hosp, Dept Radiol & Nudear Med, Oslo, Norway

[25] Univ Geneva, Memory Clin, Dept Rehabil & Geriatr, Geneva, Switzerland

[26] Univ Hosp, Geneva, Switzerland

[27] Lund Univ, Clin Memory Res Unit, Malmo, Sweden

[28] Skane Univ Hosp, Memory Clin, Malmo, Sweden

[29] Univ Manchester, Wolfson Mol Imaging Ctr, Div Neurosci & Expt Psychol, Manchester, Lancs, England

[30] Mayo Clin, Dept Radiol, Rochester, MN USA

[31] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA

[32] Univ Utah, Dept Radiol & Imaging Sci, Salt Lake City, UT USA

[33] Univ Genoa, Dept Neurosci Rehabil Ophthalmol Genet & Child &, Genoa, Italy

[34] Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden

[35] Lund Univ, Clin Memory Res Unit, Lund, Sweden

[36] Humanitas Univ, Milan, Italy

[37] Humanitas Clin & Res Ctr, Dept Nucl Med, Milan, Italy

[38] Rijnstate, Dept Radiol & Nudear Med, Arnhem, Netherlands

[39] Radhoud UMC, Dept Radiol & Nucl Med, Nijmegen, Netherlands

[40] Univ Vita Salute San Raffaele, San Raffaele Hosp, San Raffaek Sci Inst, Nudear Med Unit,Div Neurosci, Milan, Italy

[41] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA

[42] Univ Calif San Francisco, Dept Radiol, San Francisco, CA USA

[43] Univ Calif San Francisco, Dept Biomed Imaging, San Francisco, CA 94143 USA

[44] Austin Hlth, Dept Mol Imaging & Therapy, Heidelberg, Vic, Australia

[45] Univ Melbourne, Austin Hlth, Dept Med, Heidelberg, Vic, Australia

[46] Edith Cowan Univ, Sch Med & Hlth Sci, Perth, WA, Australia

[47] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Molndal, Sweden

[48] Sahlgrensk Univ Hosp, Clin Neurochem Lab, Molndal, Sweden

[49] UCL, UK Dementia Res Inst, London, England

[50] Univ Cologne, Fac Med, Dept Nucl Med, Cologne, Germany

来源：

LANCET NEUROLOGY | 2020年 / 19卷 / 11期

关键词：

MILD COGNITIVE IMPAIRMENT; PROGRESSIVE SUPRANUCLEAR PALSY; CEREBROSPINAL-FLUID BIOMARKERS; POSITRON-EMISSION-TOMOGRAPHY; DIFFERENTIAL-DIAGNOSIS; CLINICAL-DIAGNOSIS; NATIONAL INSTITUTE; CSF BIOMARKERS; FDG-PET; A-BETA;

D O I：

10.1016/S1474-4422(20)30314-8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Various biomarkers are available to support the diagnosis of neurodegenerative diseases in clinical and research settings. Among the molecular imaging biomarkers, amyloid-PET, which assesses brain amyloid deposition, and F-18-fluorodeoxyglucose (F-18-FDG) PET, which assesses glucose metabolism, provide valuable and complementary information. However, uncertainty remains regarding the optimal timepoint, combination, and an order in which these PET biomarkers should be used in diagnostic evaluations because conclusive evidence is missing. Following an expert panel discussion, we reached an agreement on the specific use of the individual biomarkers, based on available evidence and clinical expertise. We propose a diagnostic algorithm with optimal timepoints for these PET biomarkers, also taking into account evidence from other biomarkers, for early and differential diagnosis of neurodegenerative diseases that can lead to dementia. We propose three main diagnostic pathways with distinct biomarker sequences, in which amyloid-PET and F-18-FDG-PET are placed at different positions in the order of diagnostic evaluations, depending on clinical presentation. We hope that this algorithm can support diagnostic decision making in specialist clinical settings with access to these biomarkers and might stimulate further research towards optimal diagnostic strategies.

引用

页码：951 / 962

页数：12

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