Cobalt-Mediated Reactions of Oxazoles and Thiazoles with Alkynes

被引：4

作者：

Eichberg, Michael J. ^{[1
]}

Leca, Dominique ^{[1
]}

Vollhardt, K. Peter C. ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

来源：

SYNTHESIS-STUTTGART | 2015年 / 47卷 / 21期

关键词：

alkynes; C-H bond activation; cycloaddition; heterocycles; transition metals; CATALYZED DIRECT ARYLATION; N-H ACTIVATION; C-H; COBALTACYCLOPENTADIENE COMPLEXES; STRUCTURAL-CHARACTERIZATION; MOLECULAR-STRUCTURE; GOLD(I) COMPLEXES; AZOLES; DERIVATIVES; MECHANISM;

D O I：

10.1055/s-0034-1378820

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An experimental foray into the potential of oxazoles and thiazoles to enter into CpCo-mediated [2+2+2] cycloadditions is described. alpha,omega-Diynes failed to engage the heterocycles productively, as illustrated by the behavior of the unique cobaltacyclopentadiene(oxazole) complex 10, the isolation and X-ray structural determination of which is recorded. Alkyne-tethered systems gave moderate yields to products resulting from [2+2+2] cycloaddition and C-H activation. The azaenol ether bridge in the cycloaddition products appears sensitive to oxidation, elimination, and rearrangement, depending on the system and reaction conditions.

引用

页码：3412 / 3422

页数：11

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