COVID-19 IN SOLID ORGAN TRANSPLANT RECIPIENTS : INITIAL REPORT FROM NATIONAL MULTICENTER OBSERVATIONAL STUDY "ROKKOR-RECIPIENT"

被引：2

作者：

Gautier, S., V ^{[1
,2
]}

Shevchenko, A. O. ^{[1
,3
]}

Tsirulnikova, O. M. ^{[1
,2
]}

Khomyakov, S. M. ^{[1
]}

Kotenko, O. N. ^{[4
]}

Vinogradov, V. E. ^{[4
,5
]}

Abyzov, I. N. ^{[6
]}

Avetisyan, G. D. ^{[7
]}

Anisimov, A. Yu ^{[8
]}

Artyukhina, L. Yu ^{[4
]}

Bekov, M. T. ^{[1
]}

Berdinsky, V. A. ^{[4
]}

Bogdanov, V. S. ^{[4
]}

Bykov, A. Yu ^{[9
]}

Vinokurov, A. Yu ^{[10
]}

Goncharova, A. Yu ^{[1
]}

Evdokimov, D. P. ^{[11
]}

Ezersky, D., V ^{[12
]}

Zagainov, V. E. ^{[13
]}

Zakharevich, V. M. ^{[1
,2
]}

Zelenin, K. N. ^{[14
]}

Ivanova, E. S. ^{[4
]}

Kartashev, A. A. ^{[1
]}

Kvadratova, N. G. ^{[1
]}

Kim, I. G. ^{[4
]}

Koloskova, N. N. ^{[1
]}

Korobka, V. L. ^{[15
]}

Kurbanuglov, I. R. ^{[1
]}

Lysenko, M. A. ^{[4
]}

Miloserdov, I. A. ^{[1
,2
]}

Moisyuk, Ya G. ^{[16
]}

Nikolaev, G., V ^{[17
]}

Ostrovskaya, I., V ^{[4
]}

Petrova, N. Yu ^{[18
]}

Petryaev, A., V ^{[19
]}

Pinchuk, A., V ^{[20
]}

Platonov, V. S. ^{[21
]}

Poptsov, V. N. ^{[1
]}

Porchkhidze, Z. A. ^{[1
]}

Saydulaev, D. A. ^{[1
]}

Sapozhnikov, A. D. ^{[22
]}

Semchenko, S. B. ^{[23
]}

Skorobogatov, M. M. ^{[21
]}

Tereshchenko, V. Yu ^{[24
]}

Frolova, N. F. ^{[4
]}

Khalikova, D., V ^{[1
]}

Khalilulin, T. A. ^{[1
,2
]}

机构：

[1] Shumakov Natl Med Res Ctr Transplantol & Artifici, Moscow, Russia

[2] Sechenov Univ, Moscow, Russia

[3] Pirogov Med Univ, Moscow, Russia

[4] City Clinial Hosp 52, Moscow City Sci & Pract Ctr Nephrol & Transplant, Moscow, Russia

[5] Res Inst Hlth Care Org & Med Management, Moscow, Russia

[6] Republican Clin Hosp, Cheboksary, Russia

[7] Clin Hosp 1, Smolensk, Russia

[8] City Clin Hosp 7, Kazan, Russia

[9] State Novosibirsk Reg Clin Hosp, Novosibirsk, Russia

[10] Leningrad Reg Clin Hosp, St Petersburg, Russia

[11] Reg Clin Hosp, Krasnoyarsk, Russia

[12] Sergeev Reg Clin Hosp 1, Khabarovsk, Russia

[13] Volga Reg Med Ctr, Nizhnii Novgorod, Russia

[14] Minist Hlth Arkhangelsk Oblast, Arkhangelsk, Russia

[15] Rostov Reg Clin Hosp, Rostov Na Donu, Russia

[16] Vladimirsky Moscow Reg Res Clin Inst, Moscow, Russia

[17] Almazov Natl Med Res Ctr, St Petersburg, Russia

[18] Saratov Reg Clin Hosp, Saratov, Russia

[19] Tula Reg Clin Hosp, Tula, Russia

[20] Sklifosovsky Res Inst Emergency Care, Moscow, Russia

[21] Dist Clin Hosp, Khanty Mansiysk, Russia

[22] Shumakov Natl Med Res Ctr Transplantol & Artifici, Volzhsky, Russia

[23] Reg Clin Hosp 1, Ctr Organ & Tissue Transplantat, Tyumen, Russia

[24] Kabanov City Clin Hosp 1, Omsk, Russia

来源：

VESTNIK TRANSPLANTOLOGII I ISKUSSTVENNYH ORGANOV | 2020年 / 22卷 / 03期

关键词：

organ transplantation; pandemic; COVID-19; SARS-CoV-2; risk factors; Russian Transplant Society; WUHAN; CHINA;

D O I：

10.15825/1995-1191-2020-3-8-17

中图分类号：

R3 [基础医学]; R4 [临床医学];

学科分类号：

1001 ; 1002 ; 100602 ;

摘要：

We herein present our initial report from "ROKKOR-recipient", a national multicenter observational study. The prevalence, risk factors, clinical manifestations and outcomes of the novel coronavirus disease 2019 (COVID-19) in solid organ transplant recipients receiving immunosuppressive therapy were investigated. The study enrolled 251 COVID-19 patients (220 kidney recipients, 7 liver recipients, 1 liver-kidney recipient, and 23 heart recipients). The subjects came from 20 regions in Russia. The symptoms, clinical presentation, imaging and lab test results, therapy and outcomes of COVID-19 were described. It was established that solid organ transplant recipients with COVID-19 have a higher risk of developing adverse events. Predictors of adverse events include associated cardiovascular diseases, pulmonary diseases, diabetes, and kidney failure. Symptoms of the disease include dyspnea, rash and catarrhal signs, as well as initial low blood oxygen saturation (SpO(2) <92%), leukocytosis (white blood cell count >10 x 10(9)/L), elevated creatinine levels (>130 mu mol/L) and a marked decrease in glomerular filtration rate, requiring hemodialysis. Performing organ transplant surgery in COVID-19 does not increase the risk of adverse events but could save the lives of waitlisted terminally ill patients.

引用

页码：8 / 17

页数：10

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