High expression of UNC5B enhances tumor proliferation, increases metastasis, and worsens prognosis in breast cancer

被引：20

作者：

Wu, Shijie ^{[1
,2
]}

Guo, Xinyue ^{[3
]}

Zhou, Jiaojiao ^{[1
,2
]}

Zhu, Xuan ^{[4
]}

Chen, Huihui ^{[1
,2
]}

Zhang, Kun ^{[1
,2
]}

Lu, Yuexin ^{[1
,2
]}

Chen, Yiding ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 2, Dept Breast Surg, Sch Med, Hangzhou 310009, Zhejiang, Peoples R China

[2] Zhejiang Univ, Key Lab Canc Prevent & Intervent, China Natl Minist Educ, Sch Med, Hangzhou 310009, Zhejiang, Peoples R China

[3] Zhejiang Univ, Womens Hosp, Dept Obstet & Gynecol, Sch Med, Hangzhou 310009, Zhejiang, Peoples R China

[4] Zhejiang Univ, Affiliated Hosp 1, Dept Radiat Oncol, Sch Med, Hangzhou 310009, Zhejiang, Peoples R China

来源：

AGING-US | 2020年 / 12卷 / 17期

基金：

中国国家自然科学基金;

关键词：

UNC5B; breast cancer; prognosis; metastasis; functional networks; GENE-EXPRESSION; CLINICAL-SIGNIFICANCE; CELL-DEATH; WEB SERVER; PHASE IB; NETRIN-1; RECEPTOR; SURVIVAL; CHEMOTHERAPY; CARCINOMAS;

D O I：

10.18632/aging.103639

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

UNC-5 Homolog B (UNC5B) is a member of the dependence receptor family that regulates cell survival and apoptosis in a ligand-dependent manner. UNC5B plays an important role in the development of multiple cancers, including colorectal, bladder, and thyroid cancer. However, the exact expression pattern and mechanism of UNC5B in breast cancer have not been well elucidated. Here, we showed that UNC5B expression was significantly upregulated in breast cancer using bioinformatics analysis and experimental validation. High UNC5B expression was correlated with poor overall survival in breast cancer patients. UNC5B knockdown inhibited breast cancer cell proliferation and metastasis and compromised PI3K/Akt signaling activation. In summary, UNC5B is a promising diagnostic and prognostic biomarker and targeting UNC5B is a potential strategy for individualized breast cancer treatment.

引用

页码：17079 / 17098

页数：20

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