Phase transfer-catalyzed synthesis of highly acrylated hyaluronan

被引：11

作者：

Becher, Jana ^{[1
]}

Moeller, Stephanie ^{[1
]}

Schnabelrauch, Matthias ^{[1
]}

机构：

[1] INNOVENT eV, Biomat Dept, D-07745 Jena, Germany

来源：

CARBOHYDRATE POLYMERS | 2013年 / 93卷 / 02期

关键词：

Hyaluronan; Degradation; Low molecular weight; Hydrogel; Acrylate; Photo-cross-linking; MESENCHYMAL STEM-CELLS; ACID-BASED HYDROGEL; CROSS-LINKING; DERIVATIVES; DEXTRAN;

D O I：

10.1016/j.carbpol.2012.12.056

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Glycosaminoglycans and its derivatives have gained increasing attention for the fabrication of hydrogels usable in biomedicine. Starting from high molecular weight hyaluronan, a natural glycosaminoglycan that forms a mayor component of the native extracellular matrix, we present an efficient phase-transfer-based synthesis for low molecular weight hyaluronan acrylates with a tailored degree of substitution (DS) ranging up to DS values of 1.7. The ability of these compounds to form dimensionally stable hydrogels was proven using different photo-initiator systems. (C) 2012 Elsevier Ltd. All rights reserved.

引用

收藏

页码：438 / 441

页数：4

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