Subcutaneous Panniculitis-Like T-Cell Lymphoma in Two Pediatric Patients: An HIV-Positive Adolescent and a 4-Month-Old Infant

被引:8
作者
Acree, Sara C. [1 ]
Tovar, Jason P. [2 ]
Pattengale, Paul K. [2 ]
Wang, Larry L. [2 ]
Church, Joseph A. [3 ,4 ]
Gaynon, Paul S. [4 ,5 ]
Cassarino, David S. [6 ]
机构
[1] LAC USC Med Ctr, Dept Pathol, Los Angeles, CA USA
[2] Childrens Hosp Los Angeles, Dept Pathol, Los Angeles, CA 90027 USA
[3] USC, Childrens Hosp Los Angeles, Dept Pediat, Div Clin Immunol & Allergy, Los Angeles, CA USA
[4] USC, Keck Sch Med, Los Angeles, CA USA
[5] USC, Childrens Hosp Los Angeles, Dept Pediat, Div Hematol Oncol, Los Angeles, CA USA
[6] So Calif Permanente Med Grp, Dept Pathol, Los Angeles, CA 90027 USA
关键词
subcutaneous panniculitis-like T-cell lymphoma (SPTCL); SPTCL and pediatrics; SPTCL and children; SPTCL and HIV; PROGNOSTIC-FACTORS; CLASSIFICATION;
D O I
10.3109/15513815.2012.701264
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Subcutaneous Panniculitis-like T-cell lymphoma (SPTCL) is a rare subtype of childhood non-Hodgkin lymphoma. Subcutaneous Panniculitis-like T-cell lymphoma has an aggressive variant associated with the hemophagocytic syndrome (HPS). Patients without HPS show resolution of the disease with prednisone or immunosuppressive therapy unlike other T-cell lymphomas. One HIV-positive adolescent and one infant with multiple subcutaneous masses are presented and the literature is reviewed. Lesional cells were consistent with SPTCL alpha-beta type. Our cases, without HPS, showed complete resolution of their lesions when treated with non-aggressive therapies. Patients with SPTCL alpha-beta should be treated conservatively.
引用
收藏
页码:175 / 183
页数:9
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