Total Synthesis of Dictyodendrins B and E

被引：54

作者：

Liang, Jingjing ^{[1
]}

Hu, Weimin ^{[1
]}

Tao, Pengyu ^{[1
]}

Jia, Yanxing ^{[1
,2
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 78卷 / 11期

基金：

中国国家自然科学基金;

关键词：

CASCADE REACTIONS; ATOM ECONOMY; TELOMERASE; INDOLES; HETEROANNULATION; INHIBITORS; TARGET; TOOL;

D O I：

10.1021/jo400841d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The concise synthesis of the novel telomerase inhibitors dictyodendrins B and E was completed in only 9 and 11 steps (longest linear sequence). The highly convergent strategy employed a palladium-catalyzed Larock indole synthesis and a palladium-mediated one-pot consecutive Buchwald-Hartwig amination/C H activation reaction as key steps. The present synthesis exhibits respectable levels of atom-, redox-, and step-economy.

引用

收藏

页码：5810 / 5815

页数：6

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