Inhibition of jack bean urease by organobismuth compounds

被引：24

作者：

Murafuji, T ^{[1
]}

Azuma, T

Miyoshi, Y

Ishibashi, M

Rahman, AFMM

Migita, K

Sugihara, Y

Mikata, Y

机构：

[1] Yamaguchi Univ, Fac Sci, Dept Chem, Yamaguchi 7538512, Japan

[2] Nara Womens Univ, Fac Sci, Dept Chem, Nara 6308506, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 06期

基金：

日本学术振兴会;

关键词：

bismuth; organobismuth; jack bean urease; urease inhibitor; Helicobacter pylori;

D O I：

10.1016/j.bmcl.2005.12.034

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Inhibitory activity of organobismuth compounds, triarylbismuthanes 1 and their dihalides 2 and 3, was examined against jack bean urease. Besides triarylbismuth dichlorides 2, triarylbismuth difluorides 3 and bismuthanes 1 exhibited the activity. Of all these compounds, triphenylbismuth difluoride 3a and tris(4-fluorophenyl)bismuth dichloride 2b showed the highest activity. These results indicate that generation of the inhibitory effect is not always governed by the Lewis acidity at the bismuth center. Such a tendency of inhibition by the organobismuth compounds is in good accord with that observed in the antibacterial activity against Helicobacter pylori, suggesting that H. pylori-produced urease may be a therapeutic target by bismuth-based drugs. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1510 / 1513

页数：4

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