The substrates of Plk1, beyond the functions in mitosis

被引：43
作者：
Liu, X. Shawn [1 ]
Song, Bing [2 ]
Liu, Xiaoqi [1 ,3 ]
机构：
[1] Purdue Univ, Dept Biochem, W Lafayette, IN 47907 USA
[2] Purdue Univ, Dept Biol Sci, W Lafayette, IN 47907 USA
[3] Purdue Univ, Ctr Canc Res, W Lafayette, IN 47907 USA
来源：
PROTEIN & CELL | 2010年 / 1卷 / 11期
关键词：
Polo-like kinase 1; phosphorylation; substrates;
D O I：
10.1007/s13238-010-0131-x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Polo-like kinase 1 (Plk1) is a key regulator of cell division in eukaryotic cells. In this short review, we briefly summarized the well-established functions modulated by Plk1 during mitosis. Beyond mitosis, we focused mainly on the unexpected processes in which Plk1 emerges as a critical player, including microtubule dynamics, DNA replication, chromosome dynamics, p53 regulation, and recovery from the G2 DNA-damage checkpoint. Our discussion is mainly based on the critical substrates targeted by Plk1 during these cellular events and the functional significance associated with each phosphorylation event.
引用
收藏
页码：999 / 1010
页数：12
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