Preoperative C-reactive protein is predictive of long-term outcome after coronary artery bypass surgery

Background: Increased levels of C-reactive protein (CRP) are associated with the presence and severity of atherosclerosis, and with increased risk of coronary events as welt as of cardiac events after coronary percutaneous intervention. Methods: We have investigated whether preoperative CRP had an impact on the tong-term outcome of 843 patients who underwent on-pump coronary artery bypass surgery (CABG). Results: Among operative survivors, patients with preoperative CRIP < 1.0 mg/dL had significantly better 12-year overall survival rate (74.1 % vs 63.0%, p = 0.004) and survival freedom from fatal cardiac event (86.7% vs 78.1%). Muttivariate analysis including patients' age, extracardiac arteriopathy, urgent/emergent operation, recent myocardial infarction, congestive heart failure, left ventricular ejection fraction, atrial fibrillation, transient ischemic attack/ stroke, number of distal anastomoses, diabetes, and preoperative CRP >= 1.0 mg/dL or < 1.0 mg/dL, showed that the latter was an independent predictor of late all-cause mortality (p = 0.017, RR1.60, 95%Cl 1.09-2.35). Its impact on overall survival was particularly evident inpatients with left ventricular ejection fraction < 50% (CRP < 1.0 mg/dL: 58.7% vs CRP > 1.0 mg/dL: 43.7%, p < 0.00001). Conclusions: Increased preoperative levels of CRP are associated with significantly decreased overall survival after primary on-pump CABG. (c) 2006 Elsevier B.V. All rights reserved.