Severe acute respiratory syndrome related coronavirus is inhibited by interferon-α

被引：154
作者：
Ströher, U
DiCaro, A
Li, Y
Strong, JE
Aoki, F
Plummer, F
Jones, SM
Feldmann, H
机构：
[1] Univ Manitoba, Dept Med Microbiol, Winnipeg, MB, Canada
[2] Univ Manitoba, Dept Immunol, Winnipeg, MB, Canada
[3] Hlth Canada, Natl Microbiol Lab, Winnipeg, MB, Canada
[4] Ist Nazl Malattie Infett L Spallanzani IRCCS, Lab Virol Padigl Baglivi, Rome, Italy
来源：
JOURNAL OF INFECTIOUS DISEASES | 2004年 / 189卷 / 07期
关键词：
D O I：
10.1086/382597
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Current treatment schemes for severe acute respiratory syndrome (SARS) include broad-spectrum antibiotics, glucocorticoids, and ribavirin. We evaluated the susceptibility of the SARS-related coronavirus (SARS CoV) to ribavirin and interferon (IFN)-alpha in vitro by use of cytopathic effect, plaque assay, and immunoblot analysis. Ribavirin did not inhibit viral growth at concentrations attainable in human serum. In contrast, IFN-alpha showed an in vitro inhibitory effect starting at concentrations of 1000 IU/mL. In conclusion, ribavirin alone is unlikely to be beneficial in the prophylaxis or treatment of SARS CoV infections. Clinical trials with IFN-alpha might be justified to determine a beneficial effect on the outcome of SARS.
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页码：1164 / 1167
页数：4
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