The cyclin-dependent kinase inhibitor p27(Kip1) degraded in a phosphorylation- and ubiquitin-dependent way upon cell-cycle entry. p45(SKP2), the adaptor subunit of the ubiquitin-protein ligase SCFSKP2, may mediate recognition and ubiquitination or phosphorylated p27(Kip1).
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页码:E91 / E93
页数:3
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Amati Bruno, 1998, Frontiers in Bioscience, V3, pD250