Kip1 meets SKP2: new links in cell-cycle control

被引：51
|
作者：
Amati, B [1 ]
Vlach, J [1 ]
机构：
[1] Swiss Inst Expt Canc Res, CH-1066 Epalinges, Switzerland
来源：
NATURE CELL BIOLOGY | 1999年 / 1卷 / 04期
关键词：
D O I：
10.1038/12087
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The cyclin-dependent kinase inhibitor p27(Kip1) degraded in a phosphorylation- and ubiquitin-dependent way upon cell-cycle entry. p45(SKP2), the adaptor subunit of the ubiquitin-protein ligase SCFSKP2, may mediate recognition and ubiquitination or phosphorylated p27(Kip1).
引用
收藏
页码：E91 / E93
页数：3
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