Convenient and one-pot method for synthesis of the aminomethylene bisphosphonic acid derivatives from aldehydes

被引：0

作者：

Zhang, Xiang Zhu

Wu, Ming Shu ^{[1
]}

Huang, You

Chen, Ru Yu

机构：

[1] Inst Anyang Technol, Dept Chem Engn, Anyang 455000, Peoples R China

[2] Nankai Univ, Inst & Natl Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2006年 / 17卷 / 06期

关键词：

aminomethylene bisphosphonic acid derivatives; aldehydes; hydroxylamine hydrochloride; phosphours trichloride;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Simple, efficient and convenient synthesis of aminomethylene bisphsophonic acid derivatives in one-pot reaction using aldehydes, hydroxylamine hydrochloride, phosphours trichloride and water as starting materials in the presence of pyridine was described.

引用

页码：765 / 768

页数：4

共 17 条

[1]

ALFEREV IS, 1998, IZOBRETENIYA, V5, P510

[2]

BAMBER M, 1995, Patent No. 657462

[3]

BLUM H, 1989, Patent No. 332068

[4] Bisphosphonates in the adjuvant treatment of cancer: experimental evidence and first clinical results [J].