Expression of long noncoding RNAs in breast cancer in relation to reproductive factors and tumor characteristics

被引:11
作者
Ghafouri-Fard, Soudeh [1 ]
Taheri, Mohammad [2 ]
Omrani, Mir Davood [2 ]
Oskooei, Vahid Kholghi [1 ]
机构
[1] Shahid Beheshti Univ Med Sci, Dept Med Genet, Tehran, Iran
[2] Shahid Beheshti Univ Med Sci, Urogenital Stem Cell Res Ctr, Tehran 1985717443, Iran
关键词
breast cancer; FAS-anti sense 1 (FAS-AS1); nuclear-enriched abundant transcript 1 (NEAT1); OPA-interacting protein 5-AS1 (OIP5-AS1); taurine upregulated 1 (TUG1); TUG1; PROLIFERATION; METASTASIS; CARCINOMA; ANTISENSE; ESTROGEN; LNCRNA; NEAT1;
D O I
10.1002/jcb.28671
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Long noncoding RNAs (lncRNA) regulate expressions of several cancer-related genes and pathways. Expression profiling of lncRNAs would pave the way for identification of dysregulated pathways in cancer. We assessed expression of FAS-anti sense 1 (FAS-AS1), Taurine Upregulated 1 (TUG1), OPA-interacting protein 5-AS1 (OIP5 -AS1), nuclear-enriched abundant transcript 1 (NEAT1), and highly upregulated in liver cancer (HULC) in breast tumor tissues and adjacent noncancerous tissues (ANCTs). TUG1 was downregulated in tumoral tissues. We found associations between TUG1 expression and mitotic rate, NEAT1 expression and breast feeding duration as well as FAS-AS1 and OPI5 expressions and menarche age. A combination of transcript levels of all genes had 88.5% sensitivity and 42.3% specificity in breast cancer diagnosis. The current study provides evidence for the contribution of lncRNAs in breast cancer in relation to reproductive factors and tumor characteristics.
引用
收藏
页码:13965 / 13973
页数:9
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