A Review on Biomedical Application of Polysaccharide-Based Hydrogels with a Focus on Drug Delivery Systems

被引:45
|
作者
Far, Bahareh Farasati [1 ]
Naimi-Jamal, Mohammad Reza [1 ]
Safaei, Maryam [2 ]
Zarei, Kimia [3 ]
Moradi, Marzieh [4 ]
Nezhad, Hamed Yazdani [5 ]
机构
[1] Iran Univ Sci & Technol, Dept Chem, Res Lab Green Organ Synth & Polymers, Tehran 1684613114, Iran
[2] Eastern Mediterranean Univ, Fac Pharm, Dept Pharmacol, TR-99628 Famagusta, Turkey
[3] Islamic Azad Univ, Fac Pharm & Pharmaceut Sci, Tehran Med Sci, Tehran 1916893813, Iran
[4] Shahid Beheshti Univ Med Sci, Fac Pharm, Tehran 1985717443, Iran
[5] City Univ London, Dept Mech Engn & Aeronaut, London EC1V 0HB, England
基金
英国工程与自然科学研究理事会;
关键词
polysaccharide; drug delivery; hydrogel; bioengineering; biomedical application; HYALURONIC-ACID HYDROGEL; CONTROLLED-RELEASE; INJECTABLE HYDROGELS; ANTICANCER DRUG; IN-VITRO; PH; COMPOSITE; MICELLE; ANTIBACTERIAL; NANOMATERIALS;
D O I
10.3390/polym14245432
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Over the last years of research on drug delivery systems (DDSs), natural polymer-based hydrogels have shown many scientific advances due to their intrinsic properties and a wide variety of potential applications. While drug efficacy and cytotoxicity play a key role, adopting a proper DDS is crucial to preserve the drug along the route of administration and possess desired therapeutic effect at the targeted site. Thus, drug delivery technology can be used to overcome the difficulties of maintaining drugs at a physiologically related serum concentration for prolonged periods. Due to their outstanding biocompatibility, polysaccharides have been thoroughly researched as a biological material for DDS advancement. To formulate a modified DDS, polysaccharides can cross-link with different molecules, resulting in hydrogels. According to our recent findings, targeted drug delivery at a certain spot occurs due to external stimulation such as temperature, pH, glucose, or light. As an adjustable biomedical device, the hydrogel has tremendous potential for nanotech applications in involved health areas such as pharmaceutical and biomedical engineering. An overview of hydrogel characteristics and functionalities is provided in this review. We focus on discussing the various kinds of hydrogel-based systems on their potential for effectively delivering drugs that are made of polysaccharides.
引用
收藏
页数:26
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