Update on Management of Cancer-Related Cachexia

被引:48
作者
Anderson, Lindsey J. [1 ]
Albrecht, Eliette D. [1 ,2 ]
Garcia, Jose M. [1 ,3 ]
机构
[1] VA Puget Sound Hlth Care Syst, GRECC, Seattle, WA 98108 USA
[2] Yale Univ, New Haven, CT 06520 USA
[3] Univ Washington, Sch Med, Dept Med, Div Gerontol & Geriatr Med, Seattle, WA 98195 USA
关键词
Cancer; Cachexia; Quality of life; Muscle loss; Body weight; Nutrition; Inflammation; Appetite; Ghrelin; Exercise; Therapy; Multimodal; Clinical management; CELL LUNG-CANCER; QUALITY-OF-LIFE; III CLINICAL-TRIAL; DOUBLE-BLIND; MEGESTROL-ACETATE; PHASE-III; EICOSAPENTAENOIC ACID; GHRELIN; ANOREXIA; PLACEBO;
D O I
10.1007/s11912-017-0562-0
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Cachexia is a metabolic syndrome driven by inflammation and characterized by loss of muscle with or without loss of fat mass. In cancer cachexia, the tumor burden and host response induce increased inflammation, decreased anabolic tone, and suppressed appetite leading to the clinical presentation of reduced body weight and quality of life (QOL). There is no approved treatment for cancer cachexia, and commonly used nutritional and anti-inflammatory strategies alone have proven ineffective for management of symptoms. Several other pharmacological agents are currently in development and have shown promise as a clinical strategy in early-phase trials. Recently, it has been proposed that multimodal strategies, with an anabolic focus, initiated early in the disease/treatment progression may provide the most therapeutic potential for symptom management. Here we review the data from recent clinical trials in cancer cachexia including pharmacological, exercise, and nutritional interventions.
引用
收藏
页数:11
相关论文
共 69 条
[1]   Clinical development of ghrelin axis-derived molecules for cancer cachexia treatment [J].
Ali, Sumbul ;
Chen, Ji-an ;
Garcia, Jose M. .
CURRENT OPINION IN SUPPORTIVE AND PALLIATIVE CARE, 2013, 7 (04) :368-375
[2]   Are there any benefits of exercise training in cancer cachexia? [J].
Argiles, Josep M. ;
Busquets, Silvia ;
Lopez-Soriano, Francisco J. ;
Costelli, Paola ;
Penna, Fabio .
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, 2012, 3 (02) :73-76
[3]   ASPEN Clinical Guidelines: Nutrition Support Therapy During Adult Anticancer Treatment and in Hematopoietic Cell Transplantation [J].
August, David Allen ;
Huhmann, Maureen B. .
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION, 2009, 33 (05) :472-500
[4]   Oral Nutritional Interventions in Malnourished Patients With Cancer: A Systematic Review and Meta-Analysis [J].
Baldwin, Christine ;
Spiro, Ayelet ;
Ahern, Roger ;
Emery, Peter W. .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2012, 104 (05) :371-385
[5]   Multimodal nutrition/anabolic therapy for wasting conditions [J].
Balstad, Trude Rakel ;
Kaasa, Stein ;
Solheim, Tora Skeidsvoll .
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2014, 17 (03) :226-235
[6]   Body composition in patients with non-small cell lung cancer: a contemporary view of cancer cachexia with the use of computed tomography image analysis [J].
Baracos, Vickie E. ;
Reiman, Tony ;
Mourtzakis, Marina ;
Gioulbasanis, Ioannis ;
Antoun, Sami .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2010, 91 (04) :1133S-1137S
[7]   Adipose tissue inflammation and cancer cachexia: Possible role of nuclear transcription factors [J].
Batista, M. L., Jr. ;
Peres, S. B. ;
McDonald, M. E. ;
Alcantara, P. S. M. ;
Olivan, M. ;
Otoch, J. P. ;
Farmer, S. R. ;
Seelaender, M. .
CYTOKINE, 2012, 57 (01) :9-16
[8]   Structural basis for accommodation of nonsteroidal ligands in the androgen receptor [J].
Bohl, CE ;
Miller, DD ;
Chen, JY ;
Bell, CE ;
Dalton, JT .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (45) :37747-37754
[9]   Patient-reported outcomes, body composition, and nutrition status in patients with head and neck cancer: Results from an exploratory randomized controlled exercise trial [J].
Capozzi, Lauren C. ;
McNeely, Margaret L. ;
Lau, Harold Y. ;
Reimer, Raylene A. ;
Giese-Davis, Janine ;
Fung, Tak S. ;
Culos-Reed, S. Nicole .
CANCER, 2016, 122 (08) :1185-1200
[10]   Phase II Study of the Novel Peptide-Nucleic Acid OHR118 in the Management of Cancer-Related Anorexia/Cachexia [J].
Chasen, Martin ;
Hirschman, Shalom Z. ;
Bhargava, Ravi .
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 2011, 12 (01) :62-67