The emergence of SARS-CoV-2 in Europe and North America

被引：258

作者：

Worobey, Michael ^{[1
]}

Pekar, Jonathan ^{[2
,3
]}

Larsen, Brendan B. ^{[1
]}

Nelson, Martha I. ^{[4
]}

Hill, Verity ^{[5
]}

Joy, Jeffrey B. ^{[6
,7
,8
]}

Rambaut, Andrew ^{[5
]}

Suchard, Marc A. ^{[9
,10
,11
]}

Wertheim, Joel O. ^{[1
,12
]}

Lemey, Philippe ^{[13
]}

机构：

[1] Univ Arizona, Dept Ecol & Evolutionary Biol, Tucson, AZ 85721 USA

[2] Univ Calif San Diego, Bioinformat & Syst Biol Grad Program, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Dept Biomed Informat, La Jolla, CA 92093 USA

[4] Fogarty Int Ctr, NIH, Bethesda, MD 20892 USA

[5] Univ Edinburgh, Inst Evolutionary Biol, Kings Bldg, Edinburgh EH9 3FL, Midlothian, Scotland

[6] Univ British Columbia, Dept Med, Vancouver, BC, Canada

[7] BC Ctr Excellence HIV AIDS, Vancouver, BC, Canada

[8] Univ British Columbia, Bioinformat Programme, Vancouver, BC, Canada

[9] Univ Calif Los Angeles, David Geffen Sch Med, Dept Biomath, Los Angeles, CA 90095 USA

[10] Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Biostat, Los Angeles, CA 90095 USA

[11] Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA

[12] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

[13] Katholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, Rega Inst, Lab Clin & Epidemiol Virol, Leuven, Belgium

来源：

SCIENCE | 2020年 / 370卷 / 6516期

基金：

欧洲研究理事会; 欧盟地平线“2020”; 加拿大健康研究院; 英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

CORONAVIRUS;

D O I：

10.1126/science.abc8169

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Accurate understanding of the global spread of emerging viruses is critical for public health responses and for anticipating and preventing future outbreaks. Here we elucidate when, where, and how the earliest sustained severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission networks became established in Europe and North America. Our results suggest that rapid early interventions successfully prevented early introductions of the virus from taking hold in Germany and the United States. Other, later introductions of the virus from China to both Italy and Washington state, United States, founded the earliest sustained European and North America transmission networks. Our analyses demonstrate the effectiveness of public health measures in preventing onward transmission and show that intensive testing and contact tracing could have prevented SARS-CoV-2 outbreaks from becoming established in these regions.

引用

页码：564 / 570

页数：7

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