Effect of Nelumbo nucifera Petal Extracts on Lipase, Adipogenesis, Adipolysis, and Central Receptors of Obesity

被引：29
作者：
Velusami, Chandrasekaran Chinampudur [1 ,2 ]
Agarwal, Amit [1 ]
Mookambeswaran, Vijayalakshmi [2 ]
机构：
[1] Nat Remedies Pvt Ltd, R&D Ctr, Bangalore 560100, Karnataka, India
[2] VIT Univ, Ctr Bioseparat Technol, Vellore 632014, Tamil Nadu, India
来源：
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2013年 / 2013卷
关键词：
BODY-FAT ACCUMULATION; DIET-INDUCED OBESITY; ANTIINFLAMMATORY ACTIVITY; PANCREATIC LIPASE; LEAVES EXTRACT; CONSTITUENTS; ANTIOXIDANT; FLAVONOIDS; RHIZOME; SEEDS;
D O I：
10.1155/2013/145925
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
N. nucifera is one among the important medicinal plants assessed for its antiobesity action in various preclinical models. The present study was aimed at investigating the antiobesity effect of methanol and successive water extracts of petals of N. nucifera by studying its effect on adipogenesis, adipolysis, lipase, serotonin (5-HT2C), cannabinoid (CNR2), melanocyte concentrating hormone (MCHR1), and melanocortin (MC4R) receptors. Both methanol and successive water extracts of N. nucifera petals had an effect on inhibition of lipid storage in adipocytes and on increasing lipolysis. N. nucifera petal methanol extract exhibited the concentration-dependent inhibitory effect on lipase activity with an IC50 value of 47 mu g/mL. N. nucifera petal extracts showed evident agonist and antagonist activity towards 5-HT2C and CNR2 receptors, respectively, while it showed no effect towards MCHR1 and MC4R receptors. Overall, methanol extract of N. nucifera petals showed better activity than successive water extract.
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页数：7
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