D-amino-acid oxidase -: an improved production of the enzyme by the yeast Trigonopsis variabilis in a laboratory fermentor

被引：5

作者：

Kujan, P ^{[1
]}

Prell, A ^{[1
]}

Safár, H ^{[1
]}

Holler, P ^{[1
]}

Plhacková, K ^{[1
]}

Sobotka, M ^{[1
]}

机构：

[1] Acad Sci Czech Republ, Inst Microbiol, CR-14220 Prague, Czech Republic

来源：

FOLIA MICROBIOLOGICA | 2001年 / 46卷 / 05期

关键词：

D O I：

10.1007/BF02814434

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The cultivation of the yeast Trigonopsis variabilis producing D-amino-acid oxidase (an enzyme participating in the transformation of cephalosporin C into 7-aminocephalosporanic acid for the production of beta-lactam antibiotics) was controlled by changes of dissolved oxygen tension and extended fermentation times. The production technology was optimized on a laboratory scale and scale-up parameters were identified.

引用

页码：427 / 431

页数：5

共 16 条

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