Proteomics of human neurodegenerative diseases

被引：26
|
作者：
Zhang, Jing [1 ]
Keene, C. Dirk [1 ]
Pan, Catherine [1 ]
Montine, Kathleen S. [1 ]
Montine, Thomas J. [1 ]
机构：
[1] Univ Washington, Harborview Med Ctr, Dept Pathol, Seattle, WA 98104 USA
来源：
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY | 2008年 / 67卷 / 10期
基金：
美国国家卫生研究院;
关键词：
Alzheimer disease; cerebrospinal fluid; mass spectrometry; neurodegeneration; Parkinson disease; proteomics;
D O I：
10.1097/NEN.0b013e318187a832
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The technology, experimental approaches, and bioinformatics that support proteomic research are evolving rapidly. The application of these new capabilities to the study of neurodegenerative diseases is providing insight into the biochemical pathogenesis of neurodegeneration as well as fueling major efforts in biomarker discovery. Here, we review the fundamentals of commonly used proteomic approaches and the outcomes of these investigations with autopsy and cerebrospinal fluid samples from patients with neurodegenerative diseases.
引用
收藏
页码：923 / 932
页数：10
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