Upregulation of FOXM1 in a subset of relapsed myeloma results in poor outcome

被引:16
作者
Gu, Chunyan [1 ,2 ]
Holman, Carol [2 ]
Sompallae, Ramakrishna [2 ,3 ]
Jing, Xuefang [2 ]
Tomasson, Michael [4 ,5 ]
Hose, Dirk [6 ]
Seckinger, Anja [6 ]
Zhan, Fenghuang [4 ,5 ]
Tricot, Guido [4 ,5 ]
Goldschmidt, Hartmut [6 ,7 ]
Yang, Ye [1 ,8 ]
Janz, Siegfried [2 ,5 ]
机构
[1] Nanjing Univ Chinese Med, Affiliated Hosp 3, Nanjing 210023, Jiangsu, Peoples R China
[2] Univ Iowa, Roy J & Lucille A Carver Coll Med, Dept Pathol, Iowa City, IA 52242 USA
[3] Univ Iowa, Roy J & Lucille A Carver Coll Med, Iowa Inst Genet, Iowa City, IA 52242 USA
[4] Univ Iowa, Roy J & Lucille A Carver Coll Med, Dept Internal Med, Iowa City, IA 52242 USA
[5] Univ Iowa, Roy J & Lucille A Carver Coll Med, Holden Comprehens Canc Ctr, Iowa City, IA 52242 USA
[6] Univ Klinikum Heidelberg, Med Klin 5, D-69120 Heidelberg, Germany
[7] Natl Ctr Tumorerkrankungen, D-69120 Heidelberg, Germany
[8] Nanjing Univ Chinese Med, Minist Educ, Key Lab Acupuncture & Med Res, Nanjing 210023, Jiangsu, Peoples R China
来源
BLOOD CANCER JOURNAL | 2018年 / 8卷
基金
中国国家自然科学基金;
关键词
THERAPEUTIC TARGET; PD-0332991; INHIBITION; BORTEZOMIB; GENES; CELLS;
D O I
10.1038/s41408-018-0060-0
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页数:5
相关论文
共 15 条
[1]  
[Anonymous], SEMIN CANC BIOL
[2]   A novel orally active small molecule potently induces G1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6 [J].
Baughn, Linda B. ;
Di Liberto, Maurizio ;
Wu, Kaida ;
Toogood, Peter L. ;
Louie, Tracey ;
Gottschalk, Rachel ;
Niesvizky, Ruben ;
Cho, Hearn ;
Ely, Scott ;
Moore, Malcolm A. S. ;
Chen-Kiang, Selina .
CANCER RESEARCH, 2006, 66 (15) :7661-7667
[3]   Elucidation and Pharmacological Targeting of Novel Molecular Drivers of Follicular Lymphoma Progression [J].
Bisikirska, Brygida ;
Bansal, Mukesh ;
Shen, Yao ;
Teruya-Feldstein, Julie ;
Chaganti, Raju ;
Califano, Andrea .
CANCER RESEARCH, 2016, 76 (03) :664-674
[4]   Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia [J].
Buchner, Maike ;
Park, Eugene ;
Geng, Huimin ;
Klemm, Lars ;
Flach, Johanna ;
Passegue, Emmanuelle ;
Schjerven, Hilde ;
Melnick, Ari ;
Paietta, Elisabeth ;
Kopanja, Dragana ;
Raychaudhuri, Pradip ;
Mueschen, Markus .
NATURE COMMUNICATIONS, 2015, 6
[5]  
Fry DW, 2004, MOL CANCER THER, V3, P1427
[6]   The prognostic landscape of genes and infiltrating immune cells across human cancers [J].
Gentles, Andrew J. ;
Newman, Aaron M. ;
Liu, Chih Long ;
Bratman, Scott V. ;
Feng, Weiguo ;
Kim, Dongkyoon ;
Nair, Viswam S. ;
Xu, Yue ;
Khuong, Amanda ;
Hoang, Chuong D. ;
Diehn, Maximilian ;
West, Robert B. ;
Plevritis, Sylvia K. ;
Alizadeh, Ash A. .
NATURE MEDICINE, 2015, 21 (08) :938-945
[7]   FOXM1 is a therapeutic target for high-risk multiple myeloma [J].
Gu, C. ;
Yang, Y. ;
Sompallae, R. ;
Xu, H. ;
Tompkins, V. S. ;
Holman, C. ;
Hose, D. ;
Goldschmidt, H. ;
Tricot, G. ;
Zhan, F. ;
Janz, S. .
LEUKEMIA, 2016, 30 (04) :873-882
[8]   Proliferation is a central independent prognostic factor and target for personalized and risk-adapted treatment in multiple myeloma [J].
Hose, Dirk ;
Reme, Thierry ;
Hielscher, Thomas ;
Moreaux, Jerome ;
Messner, Tobias ;
Seckinger, Anja ;
Benner, Axel ;
Shaughnessy, John D., Jr. ;
Barlogie, Bart ;
Zhou, Yiming ;
Hillengass, Jens ;
Bertsch, Uta ;
Neben, Kai ;
Moehler, Thomas ;
Rossi, Jean Francois ;
Jauch, Anna ;
Klein, Bernard ;
Goldschmidt, Hartmut .
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2011, 96 (01) :87-95
[9]   Dinaciclib, a novel CDK inhibitor, demonstrates encouraging single-agent activity in patients with relapsed multiple myeloma [J].
Kumar, Shaji K. ;
LaPlant, Betsy ;
Chng, Wee Joo ;
Zonder, Jeffrey ;
Callander, Natalie ;
Fonseca, Rafael ;
Fruth, Briant ;
Roy, Vivek ;
Erlichman, Charles ;
Stewart, A. Keith .
BLOOD, 2015, 125 (03) :443-448
[10]   A novel therapeutic combination using PD 0332991 and bortezomib: Study in the 5T33MM myeloma model [J].
Menu, Eline ;
Garcia, Josefina ;
Huang, Xiangao ;
Di Liberto, Maurizio ;
Toogood, Peter L. ;
Chen, Isan ;
Vanderkerken, Karin ;
Chen-Kiang, Selina .
CANCER RESEARCH, 2008, 68 (14) :5519-5523