Binding of EuIII to 1,2-Hydroxypyridinone-Modified Peptide Nucleic Acids

被引：7

作者：

de Leon, Arnie R. ^{[2
]}

Olatunde, Abiola O. ^{[1
]}

Morrow, Janet R. ^{[1
]}

Achim, Catalina ^{[2
]}

机构：

[1] SUNY Buffalo, Dept Chem, Buffalo, NY 14260 USA

[2] Carnegie Mellon Univ, Dept Chem, Pittsburgh, PA 15213 USA

来源：

INORGANIC CHEMISTRY | 2012年 / 51卷 / 23期

基金：

美国国家科学基金会;

关键词：

METAL-BINDING; COMPLEXES; LIGAND; PNA;

D O I：

10.1021/ic301790v

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Substitution of a nucleobase pair with a pair of 1,2-hydroxypyridinone (1,2-HOPO) ligands in the center of a 10-base-pair peptide nucleic acid (PNA) duplex provides a strong binding site for Eu-III as evidenced by UV thermal melting curves, UV titrations, and luminescence spectroscopy. Eu-III excitation spectra and luminescence lifetime data are consistent with Eu-III bound to both 1,2 HOPO ligands in a PNA-HOPO duplex as the major species present in solution.

引用

页码：12597 / 12599

页数：3

共 14 条

[1] CHRISTENSEN L, 1995, J PEPT SCI, V1, P175, DOI DOI 10.1002/PSC.310010304
[2] Metal-base pairing in DNA
Clever, Guido H.
Shionoya, Mitsuhiko
[J]. COORDINATION CHEMISTRY REVIEWS, 2010, 254 (19-20) : 2391 - 2402
[3] SYNTHESIS OF PEPTIDE NUCLEIC-ACID MONOMERS CONTAINING THE 4 NATURAL NUCLEOBASES - THYMINE, CYTOSINE, ADENINE, AND GUANINE AND THEIR OLIGOMERIZATION
DUEHOLM, KL
EGHOLM, M
BEHRENS, C
CHRISTENSEN, L
HANSEN, HF
VULPIUS, T
PETERSEN, KH
BERG, RH
NIELSEN, PE
BUCHARDT, O
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1994, 59 (19) : 5767 - 5773
[4] Metal binding to bipyridine-modified PNA
Franzini, Raphael M.
Watson, Richard M.
Patra, Goutam K.
Breece, Robert M.
Tierney, David L.
Hendrich, Michael P.
Achim, Catalina
[J]. INORGANIC CHEMISTRY, 2006, 45 (24) : 9798 - 9811
[5] ON CORRELATING THE FREQUENCY OF THE F-7(0)-]D-5(0) TRANSITION IN EU(3+) COMPLEXES WITH THE SUM OF NEPHELAUXETIC PARAMETERS FOR ALL OF THE COORDINATING ATOMS
FREY, ST
HORROCKS, WD
[J]. INORGANICA CHIMICA ACTA, 1995, 229 (1-2) : 383 - 390
[6] Metal-Containing Nucleic Acid Structures Based on Synergetic Hydrogen and Coordination Bonding
He, Wei
Franzini, Raphael M.
Achim, Catalina
[J]. PROGRESS IN INORGANIC CHEMISTRY, VOL 55, 2007, 55 : 545 - 611
[7] Binding of Europium(III) to a Non-Nucleosidic Phenanthroline Linker in DNA
Huang, Ching-Hui
Parish, Austin
Samain, Florent
Garo, Florian
Haener, Robert
Morrow, Janet R.
[J]. BIOCONJUGATE CHEMISTRY, 2010, 21 (03) : 476 - 482
[8] Incorporation of hydroxypyridinone ligands into self-assembled monolayers on mesoporous supports for selective actinide sequestration
Lin, YH
Fiskum, SK
Yantasee, W
Wu, H
Mattigod, SV
Vorpagel, E
Fryxell, GE
Raymond, KN
Xu, JD
[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2005, 39 (05) : 1332 - 1337
[9] Metal Binding to Ligand-Containing Peptide Nucleic Acids
Ma, Zhijie
Olechnowicz, Frank
Skorik, Yury A.
Achim, Catalina
[J]. INORGANIC CHEMISTRY, 2011, 50 (13) : 6083 - 6092
[10] An octadentate luminescent Eu(III) 1,2-HOPO chelate with potent aqueous stability
Moore, Evan G.
Jocher, Christoph J.
Xu, Jide
Werner, Eric J.
Raymond, Kenneth N.
[J]. INORGANIC CHEMISTRY, 2007, 46 (14) : 5468 - 5470

← 1 2 →