Utility of N′-((2-chloroquinolin-3-yl)methylene)-2-cyanoacetohydrazide as a Source of Biologically Active Novel Heterocycles

被引:4
|
作者
Elsayed, Galal A. [1 ]
Omara, Samir A. [1 ]
Kamel, Rabaa M. [1 ]
机构
[1] Ain Shams Univ, Fac Sci, Dept Chem, Cairo 11566, Egypt
关键词
SUBSTITUTED QUINOLINES; ACRIDONE ALKALOIDS; ANTICANCER DRUGS; DERIVATIVES; AGENTS; QUINAZOLINE; ANTAGONISTS; ANALOGS; DESIGN; ALKYL;
D O I
10.1002/jhet.2965
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The title compound is used as a precursor in synthesis of differently sized heterocyclic systems bearing quinoline moeity. Investigation of antimicrobial activity of the new products was evaluated using agar well diffusion method against six reference microbial isolates. Most of the new compounds are potent as antimicrobial agents.
引用
收藏
页码:3427 / 3433
页数:7
相关论文
共 50 条
  • [31] Synthesis, DFT, and eco-friendly insecticidal activity of some N-heterocycles derived from 4-((2-oxo-1,2-dihydroquinolin-3-yl) methylene)-2-phenyloxazol-5(4H)-one
    Ghareeb, Eman A.
    Mahmoud, Naglaa F. H.
    El-Bordany, Eman A.
    El-Helw, Eman A. E.
    BIOORGANIC CHEMISTRY, 2021, 112
  • [32] Pd(0) catalyzed three-five-component C-2-arylallylation of active methylene heterocycles:: pyrazolones, oxazolones, isoxazolones and N,N′-dimethylbarbituric acid
    Grigg, Ronald
    Sarkar, M. Ruhul A.
    Thayaparan, Abirami
    Sridharan, Visuvanathar
    Fishwick, Colin W. G.
    TETRAHEDRON, 2007, 63 (30) : 7213 - 7228
  • [33] Synthesis and Biological Activities of Novel N-(2-(5-(3-Bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl)-1,3,4-oxadiazol-2-yl)-4-chloro-6-methylphenyl) Amides
    Zhang, Yan
    Shang, Junfeng
    Li, Huan
    Liu, Hang
    Song, Haibin
    Wang, Baolei
    Li, Zhengming
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2020, 40 (03) : 787 - 793
  • [34] Novel synthesis of substituted N-(3-aryl-1,8-naphthyridin-2-yl) and N,N′-bis(3-aryl-1,8-naphthyridin-2-yl)benzene-1,4-diamines and 2-(4-((3-aryl-1,8-naphthyridin-2-yl)amino)phenyl)isoindoline-1,3-diones and their biological evaluation
    Ravi, D.
    Sakram, B.
    Ashok, K.
    Rambabu, S.
    Sonyanaik, B.
    Kurumanna, A.
    Madhu, P.
    SYNTHETIC COMMUNICATIONS, 2018, 48 (01) : 50 - 58
  • [35] Synthesis of 2-([5-(aralkyl/aryl)-1,3,4-oxadiazol-2-yl]sulfanyl}-N-(4-methyl-1,3-thiazol-2-yl)acetamides: Novel bi-heterocycles as potential therapeutic agents
    Ramzan, Muhammad S.
    Abbasi, Muhammad A.
    Aziz-ur-Rehman
    Siddiqui, Sabahat Z.
    Shah, Syed A. A.
    Ashraf, Muhammad
    Lodhi, Muhammad A.
    Khan, Farman A.
    Mirza, Bushra
    TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2018, 17 (05) : 913 - 926
  • [36] Design, Synthesis and In Vitro Anti-Cancer Evaluation of Novel Derivatives of 2-(2-Methyl-1,5-diaryl-1H-pyrrol-3-yl)-2-oxo-N-(pyridin-3-yl)acetamide
    Moghadam, Ebrahim S.
    Saravani, Farhad
    Hamel, Ernest
    Shahsavari, Zahra
    Alipour, Mohsen
    Hosseinkhani, Saman
    Ostad, Seyednasser
    Amini, Mohsen
    MEDICINAL CHEMISTRY, 2020, 16 (03) : 340 - 349
  • [37] SYNTHESIS, ANTICONVULSANT AND NEUROTOXICITY EVALUATION OF NOVEL N-(2-BENZOYLBENZOFURAN-3-YL)-4-(SUBSTITUTED) BUTANAMIDES
    Kamal, Mehnaz
    Shakya, Ashok K.
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2012, 22 (01) : 17 - 20
  • [38] Synthesis and Biological Activities of Novel 3-(((3-Bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl) methylene)amino)-substituted-benzo[d][1,2,3] triazin-4(3H)-ones
    Zhang, Yan
    Zhu, Hongwei
    Shang, Junfeng
    Wang, Baolei
    Li, Zhengming
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2019, 39 (03) : 861 - 866
  • [39] A straightforward synthesis of potentially biologically active novel urea derivatives from 1,2,3,4-tetrahydronaphthalene-2-carboxylic acids
    Akbaba, Yusuf
    MONATSHEFTE FUR CHEMIE, 2022, 153 (12): : 1251 - 1259
  • [40] Novel Sulfonamide Derivatives Carrying a Biologically Active 3,4-Dimethoxyphenyl Moiety as VEGFR-2 Inhibitors
    Ghorab, Mostafa Mohammed
    Alsaid, Mansour Sulaiman
    Nissan, Yassin Mohammed
    Ashour, Abdelkader Elbadawy
    Al-Mishari, Abdullah Abdulalrahman
    Kumar, Ashok
    Ahmed, Sheikh Fayaz
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2016, 64 (12) : 1747 - 1754