Two new isoflavonoid glucosides from the roots of Achyranthes bidentata and their activities against nitric oxide production

被引：7

作者：

Tan, Yinfeng ^{[1
]}

An, Ni ^{[1
]}

Li, Yonghui ^{[1
]}

Cheng, Shouqian ^{[1
]}

Zhang, Junqing ^{[1
]}

Zhang, Xiaopo ^{[1
]}

Li, Youbin ^{[1
]}

机构：

[1] Hainan Med Univ, Sch Pharm, Hainan Prov Key Lab R&D Trop Herbs, Haikou 571199, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2016年 / 17卷

基金：

美国国家科学基金会;

关键词：

Achyranthes bidentata; Isoflavonoid glucosides; Anti-inflammatory activities; CELLS;

D O I：

10.1016/j.phytol.2016.07.028

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new isoflavonoid glucosides, Achyranthosides A and B, were isolated from the roots of Achyranthes bidentata. Their structures were established through extensive analyses using H-1, C-13 NMR, HSQC, HMBC, NOESY, and HREISMS spectroscopic data. The structures of the new compounds are characterized by the methoxyl groups substituted on the specific positions of the phenyl rings. The two compounds were evaluated for their anti-inflammatory activities on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 murine macrophage cells. The compounds showed significant inhibition on LPS-induced NO production. (C) 2016 Phytochemical Society of Europe. Published by Elsevier Ltd. All rights reserved.

引用

页码：187 / 189

页数：3

共 9 条

[1] Chevalierinoside B and C: Two new isoflavonoid glycosides from the stem bark of Antidesma laciniatum Muell. Arg (syn. Antidesma chevalieri Beille) [J].

Djouossi, Marie Genevieve ;

Mabou, Florence Declaire ;

Tebou, Perrin Lanversin Foning ;

Ngnokam, David ;

Tapondjou, Leon A. ;

Harakat, Dominique ;

Voutquenne-Nazabadioko, Laurence .

PHYTOCHEMISTRY LETTERS, 2014, 9 :149-152

[2] Lignans from the roots of Kadsura coccinea and their inhibitory activities on LPS-induced NO production [J].

Fang, Lingzhi ;

Xie, Chunfeng ;

Wang, Hao ;

Jin, Da-Qing ;

Xu, Jing ;

Guo, Yuanqiang ;

Ma, Yonggang .

PHYTOCHEMISTRY LETTERS, 2014, 9 :158-162

[3] Pharmacological validation of in-silico guided novel nootropic potential of Achyranthes aspera L. [J].

Gawande, Dinesh Yugraj ;

Goel, Rajesh Kumar .

JOURNAL OF ETHNOPHARMACOLOGY, 2015, 175 :324-334

[4] Achyranthes bidentata Saponins Promote Osteogenic Differentiation of Bone Marrow Stromal Cells Through the ERK MAPK Signaling Pathway [J].

He, Gang ;

Guo, Wei ;

Lou, Zhiyuan ;

Zhang, Hu .

CELL BIOCHEMISTRY AND BIOPHYSICS, 2014, 70 (01) :467-473

[5] Effect of Achyranthes bidentata Blume on 3T3-L1 Adipogenesis and Rats Fed with a High-Fat Diet [J].

Oh, Sang Deog ;

Kim, Mihyun ;

Min, Byung-Il ;

Choi, Gi Soon ;

Kim, Sun-Kwang ;

Bae, Hyunsu ;

Kang, Chulhun ;

Kim, Deok-Gon ;

Park, Byoung-Jin ;

Kim, Chang Keun .

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2014, 2014

[6] The protective effects of Achyranthes bidentata root extract on the antimycin A induced damage of osteoblastic MC3T3-E1 cells [J].

Suh, Kwang Sik ;

Lee, Young Soon ;

Choi, Eun Mi .

CYTOTECHNOLOGY, 2014, 66 (06) :925-935

[7] Three New Phytoecdysteroids Containing a Furan Ring from the Roots of Achyranthes bidentata Bl. [J].

Wang, Qiu-Hong ;

Yang, Liu ;

Jiang, Hai ;

Wang, Zhi-Bin ;

Yang, Bing-You ;

Kuang, Hai-Xue .

MOLECULES, 2011, 16 (07) :5989-5997

[8]

Yang L, 2012, CHIN J NAT MEDICINES, V10, P16, DOI [10.3724/SP.J.1009.2012.00016, 10.1016/S1875-5364(12)60003-X]

[9] An Active Component of Achyranthes bidentata Polypeptides Provides Neuroprotection through Inhibition of Mitochondrial-Dependent Apoptotic Pathway in Cultured Neurons and in Animal Models of Cerebral Ischemia [J].

Yu, Shu ;

Wang, Caiping ;

Cheng, Qiong ;

Xu, Hui ;

Zhang, Shibo ;

Li, Lu ;

Zhang, Qi ;

Gu, Xiaosong ;

Ding, Fei .

PLOS ONE, 2014, 9 (10)

← 1 →